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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Photodynamic therapy in dermatology beyond non-melanoma cancer: An update
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Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

机译：非黑素瘤癌症以外的皮肤病学中的光动力疗法：最新进展

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摘要

Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.
机译：光动力疗法（PDT）在氧气存在的情况下使用光敏剂（PS）和可见光，导致产生细胞毒性的活性氧，从而破坏细胞器并导致细胞死亡。在皮肤病学中，PDT通常采取在血红素生物合成途径中局部应用前体的形式，即5-氨基乙酰丙酸（或其甲酯），从而使活性PS原卟啉IX积聚在皮肤中。由于PDT增强了皮肤重塑并解决了慢性炎症，已被用于治疗皮肤疾病，包括光化性角化病，痤疮，病毒性疣，嫩肤，牛皮癣，局限性硬皮病，一些非黑素瘤皮肤癌和红斑痣。仍需要努力减轻副作用（主要是疼痛）并改善整个过程。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2017年第9期|140-152|共13页
  • 作者

    Wen Xiang; Li Yong; Hamblin Michael R.;

  • 作者单位

    Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu 610041, Sichuan, Peoples R China|Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA|Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA;

    Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu 610041, Sichuan, Peoples R China;

    Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA|Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA|Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Photodynamic therapy; Cosmetic; Dermatology;

    机译：光动力疗法;美容;皮肤病;

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