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Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris

机译：低剂量局部用5-氨基乙酰丙酸光动力疗法治疗不同程度的寻常性痤疮

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摘要

Objectives: To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen. Methods: A self-controlled multicenter clinical trial was carried out in 15 centers throughout China. A total of 397 acne patients of grade Ⅱ-Ⅳ received 3- or 4-session PDT treatment. 5% ALA gel was applied topically to acne lesions for 1 h incubation. The lesions were irradiated by a LED light of 633 nm at dose levels of 96-120 J/cm~2. Clinical assessment was conducted before and after every treatment up to 8 weeks. Results: The effective rate overall and of grade Ⅱ, Ⅲ and Ⅳ are 82.1%, 71.6%, 79.6% and 88.2%, respectively. The effective rate rises significantly proportionally to the severity of acne (P< 0.01). No significant differences are found in the efficacy between patients received 3-session and 4-session PDT treatments (P>0.05). The count of inflammatory and noninflammatory acne lesions gradually decrease after each treatment (P<0.01) and during the 8-week follow up (P< 0.01 or P< 0.05). Maximum efficacy is obtained at 8 weeks after the treatment completion. Conclusions: A low-dose topical ALA-PDT regimen using 5% ALA, 1 h incubation and red light source of 3 treatment sessions is suggested as optimal scheme for the treatment of different severity of acne vulgaris in Chinese patients. Superior efficacy is found in severe cystic acne of grade IV with mild side effects.
机译：目的：探讨低浓度5-氨基乙酰丙酸光动力疗法（ALA-PDT）治疗不同寻常性痤疮的疗效和安全性，并优化治疗方案。方法：在中国的15个中心进行了一项自控的多中心临床试验。共有397名Ⅱ-Ⅳ级痤疮患者接受了3次或4次PDT治疗。将5％ALA凝胶局部涂抹于痤疮病变处，孵育1小时。用633nm的LED光以96-120J / cm〜2的剂量水平照射病灶。在每次治疗之前和之后进行长达8周的临床评估。结果：Ⅱ，Ⅲ，Ⅳ级总有效率分别为82.1％，71.6％，79.6％和88.2％。有效率显着增加与痤疮的严重程度成比例（P <0.01）。在接受3疗程和4疗程PDT治疗的患者之间，疗效没有显着差异（P> 0.05）。炎性和非炎性痤疮病变的计数在每次治疗后（P <0.01）和在8周的随访期间（P <0.01或P <0.05）逐渐减少。在治疗完成后的第8周可获得最大功效。结论：建议采用低剂量局部ALA-PDT方案，采用5％ALA，1 h孵育​​和3个疗程的红色光源，作为治疗不同严重程度的中国寻常痤疮的最佳方案。在严重的IV级严重囊性痤疮中发现了优越的疗效，并具有轻微的副作用。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2013年第4期|583-590|共8页
  • 作者

    Li Ma; Lei-Hong Xiang MD; Bo Yu; Rui Yin; Lei Chen; Yan Wu; Zhi-Jian Tan; Yong-Bin Liu; Hong-Qing Tian; Hui-Zhong Li; Tong Lin; Xiu-Li Wang; Yuan-Hong Li; Wei-Zheng Wang; Hui-Lan Yang; Wei Lai;

  • 作者单位

    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China;

    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China;

    Shenzhen Hospital, Peking University, Shenzhen 518036, China;

    Southwest Hospital, Third Military Medical University, Chongqing 400038, China;

    Ruijin Hospital, Medical school of Shanghai Jiaotong University, Shanghai 200025, China;

    First Hospital, Peking University, Beijing 100034, China;

    Wuhan Union Hospital, Wuhan 430022, China;

    Shenyang Seventh People's Hospital, Shenyang 110003, China;

    Shandong Provincial Hospital for Skin Diseases, Jinan 250022, China;

    Guangdong Provincial Dermatology Hospital, Guangzhou 510095, China;

    Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210042, China;

    Shanghai Skin Diseases and STD Hospital, Shanghai 200050, China;

    The First Hospital of China Medical University, Shenyang 110001, China;

    Wuhan No. 1 Hospital, Wuhan 430022, China;

    Guangzhou General Hospital of Guangzhou Military Area Command, Guangzhou 510010, China;

    The Third Affiliated Hospital of Zhongshan University, Guangzhou 510630, China;

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  • 正文语种 eng
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  • 关键词

    Acne vulgaris; Severity; Aminolevulinic acid; Photodynamic therapy;

    机译：寻常痤疮;严重性氨基乙酰丙酸;光动力疗法;

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