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首页> 外文期刊>Dermatologic surgery >Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study.
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Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study.

机译：局部使用5-氨基乙酰丙酸和强脉冲光与单独使用强脉冲光的光动力疗法在治疗寻常性痤疮中的效果：比较研究。

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BACKGROUND: Photodynamic therapy (PDT) involves the activation of a photosensitizing agent by light to produce oxygen intermediates that destroy target tissues. Topical 5-aminolevulinic acid (ALA) is converted to protoporphyrin IX, a very potent photosensitizer, which accumulates in human skin, particularly in the epidermis and its appendages. Objective: To study the effect of PDT in acne vulgaris using topical ALA and intense pulsed light (IPL). METHODS: Thirteen individuals with varying degrees of acne were treated after a 3-week washout period. Twenty percent ALA hydrochloride (DUSA Pharmaceuticals, Wilmington, MA, USA) was applied to half of the face, and after 3 hours, the whole face was exposed to intense pulsed light (Quantum SR, Lumenis, Santa Clara, CA, USA) using a 560 nm cutoff filter starting at a fluence of 26 J/cm. The procedure was done twice at 2-week intervals, and the patients were clinically evaluated on the second, fourth, and eighth weeks. RESULTS: All patients had no apparent improvement on the second week on both facial halves. In fact, some of the patients developed acute acneiform eruptions on the side treated with ALA. By the fourth week, however, most of the patients had visible improvement of facial acne that was more significant on the ALA-treated side of the face. This persisted until the eighth week post-treatment. On the other hand, the facial half treated with intense pulsed light only showed a return to baseline of their facial acne. CONCLUSION: ALA-IPL are beneficial in the management of acne vulgaris and may be used in combination with other forms of acne treatment or may be an alternative treatment for patients who do not want to take systemic retinoids.
机译：背景：光动力疗法（PDT）涉及光激活光敏剂以产生破坏目标组织的氧中间体。局部5-氨基乙酰丙酸（ALA）被转化为原卟啉IX，这是一种非常有效的光敏剂，可在人的皮肤中，尤其是在表皮及其附肢中积累。目的：利用局部ALA和强脉冲光（IPL）研究PDT对寻常性痤疮的作用。方法：在3周的冲洗期后，对13名不同程度痤疮的患者进行了治疗。将20％的ALA盐酸盐（DUSA制药公司，威斯康星州，马萨诸塞州，美国）涂在脸上的一半上，三小时后，将整个脸部暴露在强脉冲光下（Quantum SR，Lumenis，Santa Clara，CA，美国），使用始于26 J / cm的注量的560 nm截止滤光片。该程序每2周间隔进行两次，并在第二，第四和第八周对患者进行临床评估。结果：所有患者在第二周的两半面部均无明显改善。实际上，一些患者在接受ALA治疗的一侧发展为急性痤疮样爆发。然而，到第四周，大多数患者的面部痤疮可见改善，这在经ALA治疗的面部一侧更为明显。这种情况一直持续到治疗后第八周。另一方面，用强脉冲光治疗的面部一半仅显示出其面部痤疮的基线恢复。结论：ALA-IPL在寻常痤疮的治疗中是有益的，可以与其他形式的痤疮治疗联合使用，或者可以作为不想服用全身性类维生素A的患者的替代治疗。

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