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Antibacterial photodynamic therapy for dental caries: Evaluation of the photosensitizers used and light source properties

机译：龋齿的抗菌光动力疗法：使用的光敏剂和光源特性的评估

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Photodynamic therapy studies have shown promising results for inactivation of microorganisms related to dental caries. A large number of studies have used a variety of protocols, but few studies have analyzed photosensitizers and light source properties to obtain the best PDT dose response for dental caries. This study aims to discuss the photosensitizers and light source properties employed in PDT studies of dental caries. Three questions were formulated to discuss these aspects. The first involves the photosensitizer properties and their performance against Gram positive and Gram negative bacteria. The second discusses the use of light sources in accordance with the dye maximum absorbance to obtain optimal results. The third looks at the relevance of photosensitizer concentration, the possible formation of self-aggregates, and tight source effectiveness. This review demonstrated that some groups of photosensitizers may be more effective against either Gram positive or negative bacteria, that the light source must be appropriate for dye maximum absorbance, and that some photosensitizers may have their absorbance modified with their concentration. For the best results of PDT against the main cariogenic bacteria (Streptococcus mutans), a variety of aspects should be taken into account, and among the analyzed photosensitizer, erythrosin seems to be the most appropriate since it acts against this Gram positive bacteria, has a hydrophilic tendency and even at low concentrations may have photodynamic effects. Considering erythrosin, the most appropriate light source should have a maximum emission intensity at a wavelength close to 530 nm, which may be achieved with low cost LEDs.
机译：光动力疗法的研究显示灭活与龋齿有关的微生物的结果令人鼓舞。大量研究使用了各种方案，但是很少有研究分析光敏剂和光源特性以获得对龋齿的最佳PDT剂量响应。这项研究旨在讨论在龋齿的PDT研究中使用的光敏剂和光源特性。提出了三个问题来讨论这些方面。首先涉及光敏剂的特性及其对革兰氏阳性和革兰氏阴性细菌的性能。第二部分讨论了根据染料最大吸收率使用光源以获得最佳结果的方法。第三部分着眼于光敏剂浓度的相关性，可能形成的自聚集体以及严格的光源有效性。该评价表明，某些类型的光敏剂对革兰氏阳性或阴性细菌可能更有效，光源必须适合染料的最大吸收率，并且某些光敏剂的吸收率可能会随其浓度而改变。为了使PDT对主要的致癌细菌（变形链球菌）取得最佳效果，应考虑多个方面，在分析的光敏剂中，赤藓红似乎是最合适的，因为它对革兰氏阳性细菌有作用。亲水趋势甚至在低浓度下也可能具有光动力作用。考虑到赤藓红，最合适的光源应在接近530 nm的波长处具有最大发射强度，这可以通过低成本LED来实现。

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