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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Evaluation of the effect of photoactivated disinfection with Radachlorin? against Streptococcus mutans (an in vitro study)
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Evaluation of the effect of photoactivated disinfection with Radachlorin? against Streptococcus mutans (an in vitro study)

机译：评价雷达霉素光活化消毒的效果？抗变形链球菌（体外研究）

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摘要

The use of photoactivated disinfection has had a significant medical and technolog-ical effect in bacterial inactivation, as an alternative to conventional antimicrobial methods.The main goal of this study was to investigate the effect of photoactivated disinfection onStreptococcus mutans, when Radachlorin was used as a photosensitizer.Methods: Streptococcus mutans samples of two different initial concentrations were treatedwith Radachlorin gel (0.1%), irradiated by the light of a He-Ne laser (633 nm), with energydensity of 6 J/cm~2, and cell viability was evaluated after culturing.Results: It was observed that the combination of Radachlorin and laser was more effectivethan Radachlorin or laser alone (p<0.05), in reduction of S. mutans and Radachlorin wascytotoxic, in the dark, only for the lower concentration of bacteria. Lower concentration of S.mutans resulted in higher amount of killing, in the case of using Radachlorin with or withoutlaser.Conclusions: The photoactivation of Radachlorin using a He—Ne laser could inactivate S.mutans to a significant level. In addition Radachlorin might be cytotoxic in the dark, for thetower concentration of bacteria.
机译：作为常规抗菌方法的替代方法，光活化消毒的使用在细菌失活方面具有显着的医学和技术作用。本研究的主要目的是研究光活化消毒对变形链球菌的影响，当使用Radachlorin作为杀菌剂时。方法：用Radachlorin凝胶（0.1％）处理两种不同初始浓度的变形链球菌样品，用He-Ne激光（633 nm）照射，能量密度为6 J / cm〜2，细胞活力为结果：观察到，Radachlorin和激光的联合使用比Radachlorin或单独的激光更有效（p <0.05），在黑暗中仅对较低的细菌浓度降低了变形链球菌和Radachlorin的细胞毒性。 。在有或没有激光的情况下，变形链球菌的较低浓度导致更高的杀灭率。结论：使用He-Ne激光对Radachlorin进行光活化可以使变形链球菌失活到相当大的水平。此外，雷达霉素可能在黑暗中具有细胞毒性，因为塔中的细菌浓度较高。

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