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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >The effect of dimethylsulfoxide, 1-[2-(decylthio)ethyl]azacyclopentan-2-one and Labrafac~®CC on porphyrin formation in normal mouse skin during topical application of methyl 5-aminolevulinate: A fluorescence and extraction study
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The effect of dimethylsulfoxide, 1-[2-(decylthio)ethyl]azacyclopentan-2-one and Labrafac~®CC on porphyrin formation in normal mouse skin during topical application of methyl 5-aminolevulinate: A fluorescence and extraction study

机译：5-氨基乙酰丙酸甲酯局部应用过程中二甲亚砜，1- [2-（癸硫基乙基）氮杂环戊烷-2-酮和Labrafac〜CC对正常小鼠皮肤卟啉形成的影响

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In this work, the effect of 10% of dimethylsulfoxide (DMSO), 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101) and Labrafac~®CC (a mixture of caprylic and capric acid triglycerides) on porphyrin formation in mouse skin during topical application of methyl 5-aminolevulinate (MAL) was studied. The porphyrin level in mouse skin was determined by measuring directly fluorescence and by extraction method. The porphyrin fluorescence kinetics during continuous application of MAL in creams in concentrations 2, 10 and 20% (wt./wt.) for up to 7h showed that in this concentration range the kinetics of porphyrin production in the site of application does not depend significantly on the MAL concentration. After 24h of application of all studied creams the porphyrin fluorescence in the area of treatment was dramatically reduced to be about two-fold higher than the skin autofluorescence, suggesting a significant decrease of the porphyrin concentration in these sites, although in all cases traces of porphyrins were found.
机译：在这项工作中，使用10％的二甲亚砜（DMSO），1- [2-（癸硫基）乙基]氮杂环戊烷-2-酮（HPE-101）和Labrafac〜CC（辛酸和癸酸甘油三酸酯的混合物）对局部应用5-氨基乙酰丙酸甲酯（MAL）期间小鼠皮肤卟啉形成的影响。通过直接测量荧光并通过提取方法确定小鼠皮肤中的卟啉水平。浓度为2％，10％和20％（wt./wt。）的MAL乳膏中连续施用长达7h期间的卟啉荧光动力学表明，在此浓度范围内，卟啉在施用部位的生成动力学并不显着MAL浓度。在使用所有研究的乳膏24小时后，治疗区域中的卟啉荧光显着降低，比皮肤自发荧光高大约两倍，这表明这些部位中的卟啉浓度显着降低，尽管在所有情况下都有微量的卟啉被找到。

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