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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Performance of a contact textile-based light diffuser for photodynamic therapy
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Performance of a contact textile-based light diffuser for photodynamic therapy

机译：基于接触纺织品的光扩散器在光动力治疗中的性能

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Background: Medical textiles offer a unique contact opportunity that could provide value-added comfort, reliability, and safety for light or laser-based applications. We investigated a luminous textile diffuser for use in photodynamic therapy. Methods.-Textile diffusers are produced by an embroidery process. Plastic optical fibers are bent and sewn into textile to release light by macrobending. A reflective backing is incorporated to improve surface homogeneity, intensity, and safety. Clono-genic assay (MCF-7 cells) and trypan blue exclusion (NuTu19 cells) tests were performed in vitro using 0.1 μg/ml m-THPC with three textile diffusers and a standard front lens diffuser. Heating effects were studied in solution and on human skin. PDT application in vivo was performed with the textile diffuser on equine sarcoids (three animals, 50mW/cm~2, 10-20 J) and eight research animals. Lastly, computer simulations were performed to see how the textile diffuser might work on a curved object. Results: At low fluency rate, there is a trend for the textile diffuser to have lower survival rates than the front lens diffuser for both cell lines. The textile diffuser was observed to retain more heat over a long period ( > 1 min). All animals tolerated the treatments well and showed similar initial reactions. The simulations showed a likely focusing effect in a curved geometry. Conclusions: The initial feasibility and application using a textile-based optical diffuser has been demonstrated. Possibilities that provide additional practical advantages of the textile diffuser are discussed.
机译：背景：医用纺织品提供了独特的接触机会，可以为基于光或激光的应用提供增值的舒适性，可靠性和安全性。我们研究了一种用于光动力疗法的发光纺织品扩散器。方法：纺织品扩散器是通过刺绣工艺生产的。将塑料光纤弯曲并缝入纺织品，以通过宏观弯曲释放光。并入了反光背衬，以提高表面均匀性，强度和安全性。使用0.1μg/ ml的m-THPC和三个纺织扩散器和一个标准的前透镜扩散器在体外进行克隆基因测定（MCF-7细胞）和锥虫蓝排除（NuTu19细胞）测试。研究了溶液和人体皮肤上的热效应。在体内对PDT的施用是通过纺织品扩散器对马类结节动物（3只动物，50mW / cm〜2，10-20 J）和8只研究动物进行的。最后，进行了计算机仿真，以查看纺织品扩散器如何在弯曲物体上工作。结果：在低流利率下，两种细胞系的纺织品扩散器都有比前透镜扩散器低的存活率的趋势。观察到纺织品扩散器在较长时间内（> 1分钟）保留更多热量。所有动物对治疗的耐受性良好，并显示出相似的初始反应。模拟显示了弯曲几何形状中可能的聚焦效果。结论：已经证明了使用基于纺织品的光学漫射器的初步可行性和应用。讨论了提供纺织品扩散器的其他实际优点的可能性。

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