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Barrett's oesophagus and photodynamic therapy (PDT)

机译:巴雷特食管和光动力疗法(PDT)

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摘要

Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. This cancer has the fastest growing incidence of any solid tumour in the Western world. Surveillance of Barrett's oesophagus is routinely undertaken to detect early malignant transformation. However, ablative endoscopic treatments are available and these can obliterate the abnormal epithelium, allowing neo-squamous re-growth. Photodynamic therapy (PDT) using haematoporphyrin derivative (HpD)/porfimer sodium (Photofrin~®), m-tetrahydroxyphenyl chlorin (mTHPC) and 5-aminolaevulinic acid (ALA) utilise such a technique. In this non-thermal method of ablation, the photosensitisers, together with light and oxygen, produce local tissue destruction. The use of PDT ablation of Barrett's oesophagus is reviewed.
机译:巴雷特食管是食道腺癌的前体。在西方世界,这种癌症的发生率是所有实体瘤中增长最快的。常规进行Barrett食道的监视以检测早期恶性转化。但是,可以使用消融内镜治疗,这些治疗可以消除异常的上皮,从而使新鳞状细胞再生。使用血卟啉衍生物(HpD)/卟啉钠(Photofrin®),间四羟苯基二氢卟酚(mTHPC)和5-氨基戊酸(ALA)的光动力疗法(PDT)利用了这种技术。在这种非热消融方法中,光敏剂与光和氧气一起会产生局部组织破坏。回顾了Barrett食管PDT消融的使用。

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