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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Antimicrobial effects of photodynamic therapy with antiseptics on Staphylococcus aureus biofilm on titanium surface
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Antimicrobial effects of photodynamic therapy with antiseptics on Staphylococcus aureus biofilm on titanium surface

机译：抗菌剂光动力疗法对钛表面金黄色葡萄球菌生物膜的抗菌作用

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摘要

Background: S. aureus biofilm plays a predominant role in the establishment and development of peri-implantitis. It is suggested to combine different modalities as peri-implantitis treatment. The aim of this study was to evaluate the disinfection efficacy of combined application of antiseptics with PDT on Staphylococcus aureus (S. aureus) biofilm formed on titanium(Ti) disks with different surface roughness.Methods: S. aureus biofilm was incubated on polished and sandblasted large-grit acid-etched (SLA) Ti surfaces for 48 h. 72 contaminated Ti disks (36 polished, 36 SLA) were randomly divided into 6 different groups as follows: (a) PBS, (b) 0.2% chlorhexidine digluconate (CHX), (c) 3% hydrogen peroxide (H2O2), (d) PDT, (e) 0.2% CHX + PDT, and (f) 3% H2O2 + PDT. Colony forming unit (CFU) was measured to determine antimicrobial effects. Biofilm structure was assessed using scanning electron microscopy (SEM) and confocal laser scanning microscope (CLSM).Results: All disinfection methods significantly reduced bacteria amounts compared to control group on both polished and SLA Ti surfaces (P 0.001). PDT demonstrated stronger decontamination ability in eliminating S. aureus from Ti surfaces than CHX and H2O2 did (P 0.05). The combined CHX or H2O2 with PDT treatment were more effective in bacterial disinfection than a single administration of these treatments (P 0.001).Conclusion: The combination of CHX or H(2)O(2 )administration with PDT was more effective in eradicating S. aureus on both polished and SLA Ti disks in comparison with either treatment alone, suggesting that combined usage of antiseptics with PDT could be a more efficient method for the treatment of peri-implantitis.
机译：背景：金黄色葡萄球菌生物膜在种植体周围炎的建立和发展中起主要作用。建议结合不同的方式作为种植体周围炎的治疗方法。这项研究的目的是评估在表面粗糙度不同的钛（Ti）圆盘上形成的金黄色葡萄球菌（S. aureus）生物膜上联合使用PDT与杀菌剂的消毒效果。喷砂大粒度酸蚀（SLA）钛表面48小时。将72个受污染的Ti圆片（36个抛光的，36个SLA的）随机分为6个不同的组：（a）PBS，（b）0.2％的洗必太二葡萄糖酸酯（CHX），（c）3％的过氧化氢（H2O2）， ），（e）0.2％CHX + PDT和（f）3％H2O2 + PDT。测量菌落形成单位（CFU）以确定抗微生物作用。使用扫描电子显微镜（SEM）和共聚焦激光扫描显微镜（CLSM）评估生物膜的结构。结果：与对照组相比，所有消毒方法在抛光和SLA Ti表面上的细菌数量均明显减少（P <0.001）。与CHX和H2O2相比，PDT在从Ti表面清除金黄色葡萄球菌方面显示出更强的去污能力（P <0.05）。 CHX或H2O2与PDT联合使用比单次使用这些疗法更有效（P <0.001）。结论：CHX或H（2）O（2）与PDT联合使用更有效地根除细菌与单独使用任一治疗方法相比，抛光盘和SLA Ti盘上的金黄色葡萄球菌都表明，将防腐剂与PDT并用可能是一种治疗种植体周炎的更有效方法。

著录项

  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2019年第3期|382-388|共7页
  • 作者

    Cai Zhiyu; Li Yijun; Wan Yanhuang; Chen Shuai; Jiang Shan; Ge Huan; Lei Lishan; Huang Xiaojing;

  • 作者单位

    Fujian Med Univ Union Hosp, Dept Stomatol, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Prov Univ, Key Lab Stomatol, Fuzhou, Fujian, Peoples R China|Fujian Biol Mat Engn & Technol Ctr Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Biol Mat Engn & Technol Ctr Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Prov Univ, Key Lab Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Biol Mat Engn & Technol Ctr Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Prov Univ, Key Lab Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Biol Mat Engn & Technol Ctr Stomatol, Fuzhou, Fujian, Peoples R China;

    Fujian Med Univ, Sch Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Med Univ, Hosp Stomatol, 246 Yangqiao Zhong Rd, Fuzhou 350002, Fujian, Peoples R China|Fujian Prov Univ, Key Lab Stomatol, Fuzhou, Fujian, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Photodynamic therapy; Staphylococcus aureus; Titanium disk; Biofilm; Peri-implantits;

    机译：光动力疗法;金黄色葡萄球菌;钛盘;生物膜;植入物;

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