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Hypericin-glucamine antimicrobial photodynamic therapy in the progression of experimentally induced periodontal disease in rats

机译：金丝桃素-葡萄糖胺抗菌光动力疗法在大鼠实验性牙周病进展中的作用

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Objective: To evaluate the effect of antimicrobial photodynamic therapy (aPDT) using the photosensitizer hypericin-glucamine in the progression of experimentally induced periodontal disease (PD) in rats.Material and methods: Subgingival ligatures were inserted around the upper second molars of 30 rats. After 7 days (Baseline), the animals were randomly distributed into 3 experimental (n = 5) groups: Hypericin-glucamine; LED (amber LED, 700 mA, 590 nm, 90 mW, 34.10 J/cm(2)); and aPDT (Hypericin-glucamine + LED). The treated hemimaxillae were randomly chosen. The periodontal disease progression was monitored without treatment interference in the opposite hemimaxillaes, which were used as the negative control of each animal. The euthanasia was programmed according to each experimental period, 7 or 15 days after the Baseline. Microtomographic, histometric and Tartrate Resistant Acid Phosphatase (TRAP) immunohistochemistry analyses were carried out.Results: Computerized microtomography analyses indicated that the aPDT group had a significantly higher percentage of bone tissue when compared to the other 7 days experimental groups. This result was corroborated by the histometric evaluations of the furcal area. The LED-treated group presented the highest percentages of bone volume for the 15 days experimental groups, which is remarkably higher than the groups treated with Hy-g and aPDT. The histometric analyses demonstrated the control groups had greater bone loss in the proximal regions when compared to the treated groups. The aPDT led to a lower osteoclast activity at both 7 and 15 days. Thus, we can conclude that aPDT exhibits positive effects in PD treatment by promoting favorable conditions for periodontal repair.
机译：目的：评价光敏剂金丝桃素-葡萄糖胺对大鼠光致牙周病（PD）进展的抗菌光动力疗法（aPDT）的作用。材料与方法：在30只大鼠的第二磨牙上方插入龈下结扎带。 7天（基线）后，将动物随机分为3个实验组（n = 5）：金丝桃素-葡萄糖胺； LED（琥珀色LED，700 mA，590 nm，90 mW，34.10 J / cm（2））;和aPDT（Hypericin-葡萄糖胺+ LED）。随机选择治疗过的半颌。监测牙周疾病的进展，而没有在相对的半颌上进行治疗干预，将其用作每只动物的阴性对照。根据基线后7或15天的每个实验阶段对安乐死进行编程。进行了显微切片，组织测定和抗酒石酸酸性磷酸酶（TRAP）免疫组织化学分析。结果：计算机显微切片分析表明，与其他7天实验组相比，aPDT组的骨组织百分比明显更高。该结果通过对糠醛区域的组织学评估得到了证实。在15天的实验组中，LED治疗组的骨体积百分比最高，明显高于Hy-g和aPDT治疗组。直方图分析表明，与治疗组相比，对照组在近端区域的骨丢失更大。在7天和15天时，aPDT导致破骨细胞活性降低。因此，我们可以得出结论，通过促进牙周修复的有利条件，aPDT在PD治疗中显示出积极的作用。

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