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首页> 外文期刊>Plant Foods for Human Nutrition (Formerly Qualitas Plantarum) >Multidirectional Time-Dependent Effect of Sinigrin and Allyl Isothiocyanate on Metabolic Parameters in Rats
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Multidirectional Time-Dependent Effect of Sinigrin and Allyl Isothiocyanate on Metabolic Parameters in Rats

机译：芥子苷和异硫氰酸烯丙酯对大鼠代谢参数的多向时效性

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Sinigrin (SIN) and allyl isothiocyanate (AITC) are compounds found in high concentrations in Brassica family vegetables, especially in Brussels sprouts. Recently, they have been used as a nutrition supplement for their preventive and medicinal effect on some types of cancer and other diseases. In this research, nutritional significance of parent glucosinolate sinigrin 50 μmol/kg b. w./day and its degradation product allyl isothiocyanate 25 μmol/kg b. w./day and 50 μmol/kg b. w./day was studied by the evaluation of their influence on some parameters of carbohydrate and lipid metabolism in an animal rat model in vivo after their single (4 h) and 2 weeks oral administration. Additionally, the aim of this trial was to evaluate the direct action of AITC on basal and epinephrine-induced lipolysis in isolated rat adipocytes at concentration 1 μM, 10 μM and 100 μM in vitro. Sole AITC after 4 h of its ingestion caused liver triacylglycerols increment at both doses and glycaemia only at the higher dose. Multiple SIN treatment showed its putative bioconversion into AITC. It was found that SIN and AITC multiple administration in the same way strongly disturbed lipid and carbohydrate homeostasis, increasing esterified and total cholesterol, free fatty acids and lowering tracylglycerols in the blood serum. Additionally, AITC at both doses elevated insulinaemia and liver glycogen enhancement. The in vitro experiment revealed that AITC potentiated basal lipolysis process at 10 μM, and had stimulatory effect on epinephrine action at 1 μM and 10 μM. The results of this study demonstrated that the effect of SIN and AITC is multidirectional, indicating its impact on many organs like liver as well as pancreas, intestine in vivo action and rat adipocytes in vitro. Whilst consumption of cruciferous vegetables at levels currently considered “normal” seems to be beneficial to human health, this data suggest that any large increase in intake could conceivably lead to undesirable effect. This effect is potentiated with time of action of the examined compounds, whose influence is rather adverse for the majority of metabolic pathways (liver steatosis at short duration and insulinaemia, cholesterolaemia at long time treatment). Beneficial action of AITC concerned intensified hydrolysis of TG in the blood serum with a simultaneous lipolysis in adipocytes.
机译：Sinigrin（SIN）和异硫氰酸烯丙酯（AITC）是在芸苔属蔬菜中，特别是在布鲁塞尔芽菜中发现的高浓度化合物。最近，由于它们对某些类型的癌症和其他疾病具有预防和医学作用，它们已被用作营养补品。在这项研究中，母体芥子油苷芥子苷50μmol/ kg b的营养意义。 w /天及其降解产物异硫氰酸烯丙酯25μmol/ kg b。 w。/天和50μmol/ kg b。通过评估它们对动物大鼠模型中单次口服（4 h）和2周后体内碳水化合物和脂质代谢的某些参数的影响，研究了w./day。此外，该试验的目的是评估AITC对离体大鼠脂肪细胞中浓度为1μM，10μM和100μM的基础和肾上腺素诱导的脂解的直接作用。唯一的AITC摄入4小时后，在两个剂量下都会引起肝脏三酰甘油的增加，而仅在较高剂量下才会引起血糖升高。多次SIN处理显示其可能的生物转化为AITC。发现以相同方式多次给药SIN和AITC会强烈干扰脂质和碳水化合物的体内稳态，增加血清中酯化和总胆固醇，游离脂肪酸的含量并降低三苯甘油的含量。此外，两种剂量的AITC均可升高胰岛素血症和肝糖原增强。体外实验表明，AITC在10μM时可增强基础脂解过程，并在1μM和10μM时对肾上腺素作用具有刺激作用。这项研究的结果表明，SIN和AITC的作用是多方向的，表明其对许多器官（如肝，胰腺，体内肠道作用和体外大鼠脂肪细胞）的影响。虽然食用目前被认为是“正常”水平的十字花科蔬菜似乎对人体健康有益，但该数据表明，摄入量的任何大幅增加都可能导致不良影响。该作用随所检查化合物的作用时间而增强，其作用对大多数代谢途径均不利（短期持续肝脂肪变性和长时间治疗时胰岛素血症，胆固醇血症）。 AITC的有益作用涉及血清中TG的增强水解，同时脂肪细胞同时脂解。

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