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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The conserved SOCS box motif in sappressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
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The conserved SOCS box motif in sappressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

机译：细胞因子信号抑制因子中守恒的SOCS盒基序与延伸蛋白B和C结合，并可能将结合的蛋白质与蛋白酶体降解结合

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摘要

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expresion is induced by cytokine activation of the Janus kinase/ signal transducer and activator of transcription (JAK/STAT) pathway and they act as a negative feedback loop by subsequently inhibiting the JAK/STAT pathway either by direct interaction with activated JAKs or with the receptors. These intfractions are mediated at least in part by the SH2 domain of SOCS proteins but these proteins also contain a highly conserved C-terminal homology domain termed the SOCS box. Here we show that the SOCS box mediates interactions with elongins B and C, which in turn may couple SOCS proteins and their substrates to the proteasomal protein degradation pathway. Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathwny.
机译：蛋白的细胞因子信号传导（SOCS）家族的抑制剂可作为几种细胞因子信号转导途径的细胞内抑制剂。它们的表达是由Janus激酶/信号转导子和转录激活子（JAK / STAT）途径的细胞因子激活诱导的，并且它们随后通过与激活的JAK或与激活的JAK的直接相互作用抑制JAK / STAT途径而充当负反馈回路。受体。这些破坏至少部分地由SOCS蛋白的SH2结构域介导，但是这些蛋白还包含高度保守的C端同源结构域，称为SOCS盒。在这里，我们显示SOCS框介导与延伸蛋白B和C的相互作用，进而可能将SOCS蛋白及其底物偶联到蛋白酶体蛋白降解途径上。类似于含F-box的蛋白质家族，似乎SOCS蛋白质可以充当衔接子分子，将激活的细胞信号传导蛋白质靶向蛋白质降解途径。

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