Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site

TATJANA NARANDA; R. ILENE KAUFMAN

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Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site

机译：在不存在激素的情况下，结合与不同于激素结合位点的域的肽激活促红细胞生成素受体

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摘要

Applying a homology search method previ- ously described, we identified a sequeuce in the extracellular dimerization site of the erythropoietin receptor, distant from the hormone binding site. A peptide identical to that sequence was synthesized. Remarkably, it activated receptor signaling in the absence of erythropoietin. Neither the peptide nor the hormone altered the affinity of the other for the receptor; thus, the peptide does not bind to the hormone binding site. The combined activation of signal transduction by hormone and peptide was strongly synergistic. In mice, the peptide acted like the hormone, protecting against the decrease in hemat- ocrit caused by carboplatin.

机译：应用先前描述的同源搜索方法，我们发现了促红细胞生成素受体的细胞外二聚化位点中离激素结合位点较远的一个隔离区。合成与该序列相同的肽。显着地，它在不存在促红细胞生成素的情况下激活受体信号传导。肽和激素都不会改变彼此对受体的亲和力。因此，该肽不结合激素结合位点。激素和肽对信号转导的联合激活具有强烈的协同作用。在小鼠中，该肽的作用类似于激素，可防止卡铂引起的血细胞比容降低。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第13期|7569-7574|共6页
作者
TATJANA NARANDA; R. ILENE KAUFMAN;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: possible allosteric regulation and a conserved structural motif for the chloride-binding site. [J] . Ogawa H, Qiu Y, Philo J Protein Science: A Publication of the Protein Society . 2010,第3期

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3. The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand [J] . Hendrik G. Stunnenberg, Jacky Schmitt Nucleic acids research . 1993,第11期

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6. Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site [O] . Tatjana Naranda, Kenneth Wong, R. Ilene Kaufman, 2012

机译：在不存在激素的情况下，结合与不同于激素结合位点的域的肽激活促红细胞生成素受体
7. Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site [O] . Naranda, Tatjana, Wong, Kenneth, Kaufman, R. Ilene, 1999

机译：在不存在激素的情况下，结合与不同于激素结合位点的域的肽激活促红细胞生成素受体
8. Substrate Induced Conformational Studies of the Hormone Binding Domain of the Human Estrogen Receptor by Fluorine NMR [R] . Luck, L. A. 2000

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Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site

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