Experimental support for a β-propeller domain in integrin α -subunits and a calcium binding site on its lower surface

Claus Oxvig; Timothy A. Springer

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Experimental support for a β-propeller domain in integrin α -subunits and a calcium binding site on its lower surface

机译：整合素α-亚基中的β-螺旋结构域及其下表面钙结合位点的实验支持

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Integrins are large, heterodimeric surface molecules of wide importance in cell adhesion. The N-terminal half of all integrin α-subunits contains seven weak sequence repeats of ≈60 amino acids that are important in ligand binding and have been predicted to fold cooperatively into a single β-propeller domain with seven β-sheets. We provide evidence supporting this model with a mouse mAb to human Mac-1 (αMβ2, CD11b/CD18). This antibody, CBRM1/20, binds to amino acid residues that are in different repeats and are 94 residues apart in the primary structure in the loop between strands 1 and 2 of β-sheet 5 and in the loop between strands 3 and 4 of β-sheet 6.

机译：整联蛋白是在细胞粘附中具有重要意义的大的异二聚体表面分子。所有整联蛋白α亚基的N末端一半包含七个≈60个氨基酸的弱序列重复序列，这些重复序列在配体结合中很重要，并且据预测可以协同折叠成具有七个β-折叠的单个β-螺旋结构域。我们提供了针对人类Mac-1的小鼠单克隆抗体（αMβ2，CD11b / CD18）支持该模型的证据。该抗体CBRM1 / 20与不同重复序列上的氨基酸残基结合，在β-折叠5的链1和2之间的环中以及在β的链3和4之间的环中的一级结构中相距94个残基页6。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第9期|p.4870-4875|共6页
作者
Claus Oxvig; Timothy A. Springer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Critical residues for ligand binding in blade 2 of the propeller domain of the integrin alphaIIb subunit. [J] . Tamura T, Hato T, Yamanouchi J, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2004,第1期

机译：在整联蛋白αIIb亚基的螺旋结构域的叶片2中，配体结合的关键残基。
2. Folding of the N-terminal, ligand-binding region of integrin α -subunits into a β-propeller domain [J] . Timothy A. Springer Proceedings of the National Academy of Sciences of the United States of America . 1997,第1期

机译：将整联蛋白α亚基的N末端配体结合区折叠成β-螺旋结构域
3. The α2β1 integrin inhibitor rhodocetin binds to the A-domain of the integrin α2 subunit proximal to the collagen-binding site [J] . Danny S. TUCKWELL, Johannes A. EBLE The biochemical journal . 2003,第1期

机译：α2β1整合素抑制剂视紫红质结合至胶原结合位点附近的整合素α2亚基的A结构域
4. Role of Integrin Subunits in Osteoblast Maturation on Microstructured Surfaces with Different Chemistries [C] . R. Olivares-Navarrete, S.L. Hyzy, A. Almaguer-Flores, Annual meeting of the Society for Biomaterials . 2011

机译：整合素亚基在不同化学结构的微结构表面成骨细胞成熟中的作用
5. Structural studies on the myosin molecular motor: A. Evidence for a "detached" ATP site, and B. Comparison of calcium-bound and calcium-free regulatory domains. [D] . Himmel, Daniel Marc. 2001

机译：关于肌球蛋白分子马达的结构研究：A.“分离的” ATP位点的证据，B。钙结合和无钙调节域的比较。
6. Experimental support for a β-propeller domain in integrin α-subunits and a calcium binding site on its lower surface [O] . Claus Oxvig, Timothy A. Springer 1998

机译：整合素α-亚基中的β-螺旋结构域及其下表面的钙结合位点的实验支持
7. An N-Glycosylation Site on theβ-Propeller Domain of the Integrin α5 Subunit Plays Key Roles in Both Its Function and Site-specific Modification byβ1,4-N-Acetylglucosaminyltransferase III* [O] . Sato, Yuya, Isaji, Tomoya, Tajiri, Michiko, 2009

机译：N-糖基化位点在β-螺旋结构域上整合素α5亚基在其功能和功能上均起着关键作用特定于站点的修改 β1,4-N-乙酰氨基葡萄糖氨基转移酶 III *

Experimental support for a β-propeller domain in integrin α -subunits and a calcium binding site on its lower surface

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