A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

Yao-Tseng Chen; Matthew J. Scanlan; Ugur Sahin

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A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

机译：通过自身抗体筛选检测到的人类癌症中异常表达的睾丸抗原

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Serological analysis of recombinant cDNA expression libraries (SEREX) using tumor mRNA and autolo- gous patient serum provides a powerful approach to identify immunogenic tumor antigens. We have applied this method- ology to a case of esophageal squamous cell carcinoma and identified several candidate tumor targets. One of these, NY-ESO-1, showed restricted mRNA expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues.

机译：使用肿瘤mRNA和自体患者血清对重组cDNA表达文库（SEREX）进行血清学分析，为鉴定免疫原性肿瘤抗原提供了一种有力的方法。我们将这种方法学应用于一例食管鳞状细胞癌，并确定了几个候选肿瘤靶标。其中之一，NY-ESO-1在正常组织中显示受限制的mRNA表达，仅在睾丸和卵巢组织中发现高水平的mRNA表达。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1914-1918|共5页
作者
Yao-Tseng Chen; Matthew J. Scanlan; Ugur Sahin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. A TESTICULAR ANTIGEN ABERRANTLY EXPRESSED IN HUMAN CANCERS DETECTED BY AUTOLOGOUS ANTIBODY SCREENING [J] . Chen YT., Sahin U., Tureci O., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：通过自动抗体抗体筛选在人癌中异常表达的抗原性抗原。
2. Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies. [J] . Hanafusa T, Mohamed AE, Kitaoka K, Cancer letters . 2011,第1期

机译：通过自体抗体的血清学筛选来分离和表征人肺癌抗原。
3. Single-antigen-expressing cell lines are excellent tools for detecting human leukocyte antigen-C-reactive antibodies in kidney transplant recipients. [J] . Zoet YM, Eijsink C, Bohmova R, Transplantation: Official Journal of the Transplantation Society . 2005,第9期

机译：表达单抗原的细胞系是检测肾移植受者中人白细胞抗原C反应性抗体的出色工具。
4. Human Synthetic, Semi-Synthetic, and Na?ve Immune Libraries for Efficient Isolation of Antigen Specific Antibodies Isolation of Antigen Specific Antibodies [C] . Man-Seok Ju, Sang Taek Jung PEGS . 2016

机译：人合成，半合成和Na ve've免疫文库，用于有效地分离抗原特异性抗体的分离分离抗原特异性抗体
5. Pichia pastoris as a recombinant protein expression host: Secretion optimization of a single -chain antibody fragment and of a cancer -testis antigen [D] . Damasceno, Leonardo Miranda 2007

机译：巴斯德毕赤酵母作为重组蛋白表达宿主：单链抗体片段和癌睾丸抗原的分泌优化
6. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening [O] . Yao-Tseng Chen, Matthew J. Scanlan, Ugur Sahin, 1997

机译：通过自体抗体筛选发现在人类癌症中异常表达的睾丸抗原
7. Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies [O] . Hanafusa, Tadashi, Mohamed, Ali Eldib Ali, Kitaoka, Kenta, 2011

机译：通过自体抗体的血清学筛选分离和鉴定人肺癌抗原

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

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