Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A_2

Susanna Miettinen; Francesca R. Fusco; Juha Yrjanheikki

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Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A_2

机译：扩散性抑郁和局灶性脑缺血通过N-甲基-D-天冬氨酸受体和磷脂酶A_2诱导皮层神经元中的环氧合酶2

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Repetitive spreading depression (SD) waves, involving depolarization of neurons and astrocytes and up- regulation of glucose consumption, is thought to lower the threshold of neuronal death during and immediately after ischemia. Using rat models for SD and focal ischemia we investigated the expression of cyclooxygenase-1 (COX-1), the constitutive form, and cyclooxygenase-2 (COX-2), the induc- ible form of a key enzyme in prostaglandin biosynthesis and the target enzymes for nonsteroidal anti-inflammatory drugs.

机译：反复扩散性抑郁（SD）波涉及神经元和星形胶质细胞的去极化和葡萄糖消耗的上调，据认为可以降低缺血期间和缺血后神经元死亡的阈值。使用SD和局灶性缺血的大鼠模型，我们研究了环氧合酶1（COX-1）的组成形式和环氧合酶2（COX-2）的表达，前列腺素生物合成和合成过程中关键酶的诱导形式。非甾体抗炎药的目标酶。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6500-6505|共6页
作者
Susanna Miettinen; Francesca R. Fusco; Juha Yrjanheikki;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. [J] . Horiguchi T, Snipes JA, Kis B, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2006,第2期

机译：环氧合酶2介导皮质扩散抑郁症诱导的大鼠短暂性局灶性脑缺血耐受性的发展。
2. Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain. [J] . Otori T, Greenberg JH, Welsh FA Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2003,第1期

机译：皮质扩散抑制会导致脑血流长期持续减少，并诱发对大鼠脑永久性局部缺血的耐受性。
3. Induction of tolerance to focal ischemia in rat brain: dissociation between cortical lesioning and spreading depression. [J] . Muramatsu H, Kariko K, Welsh FA Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2004,第10期

机译：诱导对大鼠脑局灶性局部缺血的耐受性：皮损和扩散性抑郁之间的分离。
4. Role of Phospholipases A_2 in Cyclooxygenase-2 Expression Induced by Entamoeba Histolytica in Macrophages [C] . G. Cuellar-Nevarez, O. Mata-Leyva, B. Rivera-Chavira, International Congress of Parasitology . 2006

机译：磷脂磷酸酶A_2在巨噬细胞entamoeba组织溶解诱导的环氧氧酶-2表达中的作用
5. Age-related memory decline is associated with focal loss of cortical neurons and selective degeneration of subcortical neurons [D] . Smith, David Edward 2002

机译：年龄相关的记忆力下降与皮质神经元的局灶性丧失和皮质下神经元的选择性变性有关
6. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A2 [O] . Susanna Miettinen, Francesca R. Fusco, Juha Yrjänheikki, 1997

机译：情绪低落和局灶性脑缺血通过N-甲基-d-天冬氨酸受体和磷脂酶A2诱导皮层神经元中的环氧合酶2
7. Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia [O] . Yulius Hermanto, Tadashi Sunohara, Ahmad Faried, 2017

机译：在局灶性脑缺血的成年男性Wistar大鼠中移植饲养者的人类诱导多能干细胞衍生的皮质神经元祖细胞
8. Cortical Ph Chance Accompanying Spreading Cortical Depression and Convulsion [R] . R. D. Tschirgi, J. L. Taylor 1957

机译：皮质ph机会伴随传播的皮质抑郁和惊厥

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A_2

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