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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Induction of tolerance to focal ischemia in rat brain: dissociation between cortical lesioning and spreading depression.
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Induction of tolerance to focal ischemia in rat brain: dissociation between cortical lesioning and spreading depression.

机译：诱导对大鼠脑局灶性局部缺血的耐受性：皮损和扩散性抑郁之间的分离。

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摘要

Cortical application of KCl has previously been shown to induce tolerance to a subsequent episode of cerebral ischemia. KCl triggers recurrent episodes of cortical spreading depression and produces a small lesion at the cortical application site. To determine whether a cortical lesion alone is sufficient to induce tolerance to ischemia, the authors used 5-mol/L NaCl to precondition rat brain 3 days before permanent occlusion of the middle cerebral artery. NaCl produced a small lesion at the application site without evoking cortical spreading depression. Preconditioning with 5-mol/L NaCl significantly attenuated the decrease in CBF after middle cerebral artery occlusion and reduced the volume of cortical infarction by 35%. The results show that a small cortical lesion, by itself, is sufficient to induce tolerance to ischemia.
机译：先前已经证明，皮层施用氯化钾可诱导对随后的脑缺血发作的耐受性。 KCl引发皮质扩散性抑郁症的复发发作，并在皮质应用部位产生小病变。为了确定单独的皮层病变是否足以诱导对缺血的耐受性，作者使用5 mol / L NaCl对大脑中动脉永久性闭塞前3天进行了预处理。 NaCl在应用部位产生了一个小病灶，而没有引起皮质扩散抑制。用5 mol / L NaCl预处理可显着减弱大脑中动脉闭塞后CBF的降低，并使皮层梗死的体积减少35％。结果表明，小的皮质病变本身足以诱导对缺血的耐受性。

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