Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

Takahiro Yano; Tatsuya Nakamura; Janna Blechman

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Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

机译：ALL-1的核点状分布是由蛋白质N末端的不同元素赋予的

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The ALL-1 gene positioned at 11q23 is di- rectly involved in human acute leukemia either through a variety of chromosome translocations or by partial tandem duplications. ALL-1 is the human homologue of Drosophila trithorax which plays a critical role in maintaining proper spatial and temporal expression of the Antennapedia-bithorax homeotic genes determining the fruit fly's body pattern. Utilizing specific antibodies, we found that the ALL-1 protein distributes in cultured cells in a nuclear punctate pattern.

机译：位于11q23的ALL-1基因通过各种染色体易位或部分串联重复直接参与人类急性白血病。 ALL-1是果蝇三叶草的人类同源物，它在维持决定果蝇身体形态的触角-Bithorax同源基因的正确时空表达中起关键作用。利用特异性抗体，我们发现ALL-1蛋白以核点状分布在培养的细胞中。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7286-7291|共6页
作者
Takahiro Yano; Tatsuya Nakamura; Janna Blechman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：ALL-1的核点状分布是由蛋白的N末端的不同元素赋予的
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Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

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