Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

Antonio J. da Silva; Zhuwen Li; Cristina de Vera

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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

机译：克隆新型T细胞蛋白FYB，该蛋白结合FYN和含SH2结构域的白细胞蛋白76并调节白介素2的产生

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T cell receptor ζ (TcRξ)/CD3 ligation ini- tiates a signaling cascade that involves src kinases p56 and ζ-associated protein 70, leading to the phosphorylation of substrates such as TcRζ, Vav, SH2-domain-containing leuko- cyte protein 76 (SLP-76), cbl, and p120/130. FYN binding protein (FYB or p120/130) associates with p59, the TcRζ/ CD3 complex, and becomes tyrosine-phosphorylated in re- sponse to receptor ligation. In this study, we report the cDNA cloning of human and murine FYB and show that it is restricted in expression to T cells and myeloid cells and possesses an overall unique hydrophilic sequence with several tyrosine-based motifs, proline-based type I and type II SH3 domain binding motifs, several putative lysine/glutamic acid- rich nuclear localization motifs, and a SH3-like domain.

机译：T细胞受体ζ（TcRξ）/ CD3连接引发涉及src激酶p56和ζ相关蛋白70的信号级联反应，导致底物如TcRζ，Vav，含SH2结构域的白细胞蛋白76磷酸化（SLP-76），cbl和p120 / 130。 FYN结合蛋白（FYB或p120 / 130）与p59（TcRζ/ CD3复合物）结合，并响应受体连接而酪氨酸磷酸化。在这项研究中，我们报告了人类和鼠类FYB的cDNA克隆，并显示它在T细胞和髓样细胞的表达中受到限制，并具有带有几个基于酪氨酸的基序，基于脯氨酸的I型和II型的整体独特的亲水序列。 SH3结构域结合基序，几个假定的赖氨酸/谷氨酸富核定位基序和一个SH3样结构域。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7493-7498|共6页
作者
Antonio J. da Silva; Zhuwen Li; Cristina de Vera;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton [J] . Matthias Krause, Antonio S. Sechi, Marlies Konradt, Journal of cell biology . 2000,第1期

机译：Fyn结合蛋白（Fyb）/ Slp-76-相关蛋白（巴掌），Ena /血管舒张药刺激的磷酸蛋白（Vasp）蛋白和Arp2 / 3复杂链T细胞受体（Tcr）信号传导至肌动蛋白细胞骨架
2. Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651. [J] . Geng L, Raab M, Rudd CE The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第11期

机译：前沿：在TCR驱动的IL-2转录上调中，SLP-76与FYB / FYN-T的协同作用需要SLP-76在Tyr595和Tyr651处与FYB结合。
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机译：耶尔森氏菌酪氨酸磷酸酶YopH与巨噬细胞底物Fyn结合蛋白Fyb的相互作用
4. T-cell mimicry of streptococcal M protein and cardiac myosin epitopes by T-cell clones from rheumatic heart disease [C] . Nadia M.J. Ellis, Ya Li, William Hildebrand, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

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机译：从基于人纤维蛋白III（10FnIII）的第十个域的修饰的组合蛋白文库中选择新型激活白细胞粘附分子（ALCAM）结合蛋白的mRNA显示。
6. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production [O] . Antonio J. da Silva, Zhuwen Li, Cristina de Vera, 1997

机译：克隆新型T细胞蛋白FYB该蛋白结合FYN和含SH2结构域的白细胞蛋白76并调节白介素2的产生
7. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production [O] . A. J. da Silva, Z. Li, C. de Vera, 1997

机译：结合含Fyk和Sh2域的白细胞蛋白76的新型T细胞蛋白FYB并调节白细胞介素2的生产

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

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