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Helical repeat of DNA in the region of homologous pairing

机译:DNA在同源配对区域的螺旋重复

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摘要

The process of DNA strand exchange during general genetic recombination is initiated within protein- stabilized synaptic filaments containing homologous regions of interacting DNA molecules. The RecA protein in bacteria and its analogs in eukaryotic organisms start this process by forming helical filamentous complexes on single-stranded or partially single-stranded DNA molecules. These complexes then progressively bind homologous double-stranded DNA molecules so that homologous regions of single- and double- stranded DNA molecules become aligned in register while presumably winding around common axis.
机译:在一般的基因重组过程中,DNA链交换过程是在包含相互作用DNA分子同源区域的蛋白质稳定的突触丝内启动的。细菌中的RecA蛋白及其在真核生物中的类似物通过在单链或部分单链DNA分子上形成螺旋状丝状复合物来启动此过程。然后,这些复合物逐渐结合同源的双链DNA分子,从而使单链和双链DNA分子的同源区域在对齐时对齐,同时大概绕着公共轴缠绕。

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