Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge

Danny L. Brower; Sharon M. Brower; David C. Hayward

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Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge

机译：整联蛋白的分子进化：编码来自珊瑚和海绵的整联蛋白β亚基的基因

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The integrin family of cell surface receptors is strongly conserved in higher animals, but the evolutionary history of integrins is obscure. We have identified and se- quenced cDNAs encoding integrin β subunits from a coral (phylum Cnidaria) and a sponge (Porifera), indicating that these proteins existed in the earliest stages of metazoan evolution. The coral β_Cn1 and, especially, the sponge β_Po1 sequences are the most divergent of the "β_1-class" integrins and share a number of features not found in any other vertebrate or invertebrate integrins.

机译：在高等动物中，细胞表面受体的整联蛋白家族是高度保守的，但整联蛋白的进化史却不清楚。我们已经从珊瑚（Cnidaria）和海绵（Porifera）中鉴定并测序了编码整联蛋白β亚基的cDNA，表明这些蛋白质存在于后生动物进化的最早阶段。珊瑚β_Cn1序列，尤其是海绵β_Po1序列是“β_1类”整联蛋白中差异最大的，并具有许多其他脊椎动物或无脊椎动物整联蛋白所没有的特征。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9182-9187|共6页
作者
Danny L. Brower; Sharon M. Brower; David C. Hayward;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Intron dynamics and the evolution of integrin beta-subunit genes:Maintenance of an ancestral gene structure in the coral, Acroporamillepora [J] . Schmitt DM, Brower DL Journal of Molecular Evolution . 2001,第6期

机译：内含子动力学和整联蛋白β-亚基基因的进化：珊瑚，Acroporamillepora的祖先基因结构的维护。
2. Intron Dynamics and the Evolution of Integrin β-Subunit Genes: Maintenance of an Ancestral Gene Structure in the Coral, Acropora millepora [J] . Dasan M. Schmitt, Danny L. Brower Journal of Molecular Evolution . 2001,第6期

机译：内含子动力学和整合素β-亚基基因的进化：珊瑚，Acropora millepora的祖先基因结构的维持。
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机译：第一部分：杜卡霉素SA烷基化亚基的溶剂分解区域选择性和X射线结构。第二部分靶向促红细胞生成素受体的化合物库的溶液相合成。第三部分通过阻断蛋白酶MMP2和整联蛋白α（v）beta（3）的相互作用来识别新型血管生成抑制剂
6. Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge [O] . Danny L. Brower, Sharon M. Brower, David C. Hayward, 1997

机译：整联蛋白的分子进化：编码来自珊瑚和海绵的整联蛋白β亚基的基因
7. Molecular evolution of integrins: Genes encoding integrin subunits from a coral and a sponge [O] . D. L. Brower, S. M. Brower, D. C. Hayward, 1997

机译：整联蛋白的分子演变：从珊瑚和海绵中编码整合蛋白亚基的基因

Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge

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