Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes

Sylvie Tourne; Toru Miyazaki; Paula Wolf

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Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes

机译：主要组织相容性复合物II类分子在小鼠中的功能恒定不变，为恒定链和H-2M复合物

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By combining two previously generated null mutations, Ii deg and M deg , we produced mice lacking the invariant chain and H-2M complexes, both required for normal cell- surface expression of major histocompatibility complex class II molecules loaded with the usual diverse array of peptides. As expected, the maturation and transport of class II mole- cules, their expression at the cell surface, and their capacity to present antigens were quite similar for cells from Ii deg M deg double-mutant mice and from animals carrying just the Ii deg mutation.

机译：通过组合两个先前生成的无效突变（Ii deg和M deg），我们产生了缺少恒定链和H-2M复合体的小鼠，这两个结构都是主要的组织相容性复合体II类分子的正常细胞表面表达所必需的，这些分子装载了通常的各种肽。正如预期的那样，II型分子的成熟和运输，它们在细胞表面的表达以及它们呈递抗原的能力对于来自Ii deg M deg双突变小鼠和仅携带Ii deg突变的动物的细胞非常相似。。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9255-9260|共6页
作者
Sylvie Tourne; Toru Miyazaki; Paula Wolf;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Invariant Chain–independent Function of H-2M in the Formation of Endogenous Peptide–Major Histocompatibility Complex Class II Complexes In Vivo [J] . Susan Kovats, Catherine E. Grubin, Susan Eastman, The Journal of Experomental Medicine . 1998,第2期

机译：H-2M在体内内源性肽-主要组织相容性复合物II类复合物形成中的不变链独立功能
2. Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence. [J] . L S Arneson, J Miller Journal of cell biology . 1995,第5期

机译：有效的主要组织相容性复合物II类不变链复合物的有效内体定位需要不变链靶向序列的多聚化。
3. EXPRESSION OF ENDOGENOUS PEPTIDE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II COMPLEXES DERIVED FROM INVARIANT CHAIN-ANTIGEN FUSION PROTEINS [J] . Sanderson S., Shastri N., Frauwirth K. Proceedings of the National Academy of Sciences of the United States of America . 1995,第16期

机译：不变链抗原融合蛋白衍生的内源肽主要组织相容性复合物II类复合物的表达
4. Invariant chain regulates the major histocompatibility complex class II peptide repertoire of cell-based cancer vaccines. [C] . Olesya Y. Chornoguz, Lydia Grmai, Alexei Gapeev, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：不变链调节细胞基癌症疫苗的主要组织相容性复合体II类肽曲目。
5. Biophysical Chracterization of Class II Major Histocompatibility Complex (MHCII) Molecules [D] . Osan, Jaspreet Kaur. 2020

机译：II类主要组织相容性复合物（MHC II）分子的生物物理表征
6. Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes [O] . Sylvie Tourne, Toru Miyazaki, Paula Wolf, 1997

机译：主要组织相容性复合物II类分子在小鼠中恒定链和H-2M复合物双重缺乏的功能
7. Decreased Endosomal Delivery of Major Histocompatibility Complex Class II-invariant Chain Complexes in Dynamin-deficient Cells [O] . Kena Wang, Per A. Peterson, Lars Karlsson 1997

机译：在发动机缺陷细胞中减少主要组织相容性复合体II类不变链复合物的内体递送
8. Apoptosis Use Case: In Silico Evaluation of a Library of Small Molecule Pharmacophore Models for Blocking the Formation of SEB-Major Histocompatibility Class II Complexes [R] . Hammamieh, R. 2007

机译：细胞凋亡用例：用于阻断sEB-主要组织相容性II类复合物形成的小分子药效团模型的silico评价

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes

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