Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

Johannes V. Swinnen; William Ulrix; Walter Heyns

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Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

机译：雄激素对脂肪基因表达的协调调节：涉及甾醇调节元件结合蛋白的级联机制的证据

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To gain more insight into the molecular mechanisms by which androgens stimulate lipogenesis and induce a marked accumulation of neutral lipids in the human prostate cancer cell line LNCaP, we studied their impact on the expression of lipogenic enzymes. Northern blot analysis of the steady-state mRNA levels of seven different lipogenic enzymes revealed that androgens coordinately stimulate the expression of enzymes belonging to the two major lipogenic pathways: fatty acid synthesis and cholesterol synthesis. In view of the important role of the recently characterized sterol regulatory element binding proteins (SREBPs) in the coor- dinate induction of lipogenic genes, we examined whether the observed effects of androgens on lipogenic gene expression are mediated by these transcription factors.

机译：为了更深入地了解雄激素刺激脂肪生成并诱导中性脂质在人前列腺癌细胞系LNCaP中积累的分子机制，我们研究了它们对脂肪生成酶表达的影响。对7种不同脂肪酶的稳态mRNA的Northern印迹分析表明，雄激素协同刺激属于两种主要脂肪途径的酶的表达：脂肪酸合成和胆固醇合成。鉴于最近表征的固醇调节元件结合蛋白（SREBPs）在大幅度诱导脂肪生成基因中的重要作用，我们检查了所观察到的雄激素对脂肪生成基因表达的影响是否由这些转录因子介导。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.12975-12980|共6页
作者
Johannes V. Swinnen; William Ulrix; Walter Heyns;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：FOXO1通过转录因子Srebp-1C和LXR抑制甾醇调节元素结合蛋白-1C（Sreb-1c）基因表达，山羊乳腺上皮细胞
5. Polyunsaturated fatty acids suppress hepatic lipogenic gene transcription by accelerating sterol regulatory element binding protein-1 transcript decay. [D] . Xu, Jing. 2001

机译：多不饱和脂肪酸通过加速固醇调节元件结合蛋白1转录本的衰减来抑制肝脂肪基因的转录。
6. Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins [O] . Johannes V. Swinnen, William Ulrix, Walter Heyns, 1997

机译：雄激素对生脂基因表达的协调调控：涉及固醇调节元件结合蛋白的级联机制的证据
7. Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins [O] . Swinnen, JV, Ulrix, W, Heyns, W, 1997

机译：雄激素对生脂基因表达的协调调节：涉及固醇调节元件结合蛋白的级联机制的证据

Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

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