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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ascorbate recycling in human neutrophils: Induction by bacteria
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Ascorbate recycling in human neutrophils: Induction by bacteria

机译:人类中性粒细胞中抗坏血酸的再循环:细菌的诱导

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摘要

Ascorbate (vitamin C) recycling occurs when extracellular ascorbate is oxidized, transported as dehy- droascorbic acid, and reduced intracellularly to ascorbate. We investigated microorganism induction of ascorbate recycling in human neutrophils and in microorganisms themselves. Ascorbate recycling was determined by measuring intracellu- lar ascorbate accumulation. Ascorbate recycling in neutro- phils was induced by both Gram-positive and Gram-negative pathogenic bacteria, and the fungal pathogen Candida albi- cans. Induction of recycling resulted in as high as a 30-fold increase in intracellular ascorbate compared with neutrophils not exposed to microorganisms.
机译:当细胞外抗坏血酸被氧化,作为去氢抗坏血酸运输并在细胞内还原为抗坏血酸时,发生抗坏血酸(维生素C)循环。我们调查了人类嗜中性粒细胞和微生物自身中抗坏血酸再循环的微生物诱导。通过测量细胞内抗坏血酸的积累来确定抗坏血酸的回收利用。革兰氏阳性和革兰氏阴性病原菌以及真菌病原体白色念珠菌均诱导嗜中性粒细胞中的抗坏血酸再循环。与未暴露于微生物的嗜中性粒细胞相比,回收的诱导导致细胞内抗坏血酸盐的含量增加多达30倍。

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