Immunoregulatory properties of ISG15, an interferon-induced cytokine

Jonathan DCunha; Ernest Knight Jr; Arthur L. Haas

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Immunoregulatory properties of ISG15, an interferon-induced cytokine

机译：ISG15，干扰素诱导的细胞因子的免疫调节特性

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ISG15 is a 15-kDa protein of unique primary amino acid sequence, which is transcriptionally regulated by interferon (IFN) α and IFN-β. Because it is synthesized in many cell types and secreted from human monocytes and lymphocytes, we postulated that ISG15 might act to modulate immune cell function. ISG15 stimulated B-depleted lympho- cyte proliferation in a dose-dependent manner with signify- cant proliferation induced by amounts of ISG15 as low as 1 ng/ml (58 pM).

机译：ISG15是具有独特一级氨基酸序列的15 kDa蛋白，受干扰素（IFN）α和IFN-β的转录调控。因为它是在许多细胞类型中合成的并且从人单核细胞和淋巴细胞分泌，所以我们推测ISG15可能起调节免疫细胞功能的作用。 ISG15以剂量依赖的方式刺激B淋巴细胞的增殖，而ISG15的量低至1 ng / ml（58 pM）则可引起明显的增殖。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.211-215|共5页
作者
Jonathan DCunha; Ernest Knight Jr; Arthur L. Haas;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Immunoregulatory properties of ISG15 an interferon-induced cytokine. [O] . J DCunha, E Knight Jr, A L Haas, 1996

机译：干扰素诱导的细胞因子ISG15的免疫调节特性。
7. Immunoregulatory properties of ISG15, an interferon-induced cytokine. [O] . D'Cunha, J, Knight, E, Haas, A L, 1996

机译：干扰素诱导的细胞因子ISG15的免疫调节特性。

Immunoregulatory properties of ISG15, an interferon-induced cytokine

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