Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E

Denis Rousseau; Roger Kaspar; Igor Rosenwald

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E

机译：过量表达真核生物起始因子4E的细胞中鸟氨酸脱羧酶的翻译起始和细胞周期蛋白D1 mRNA的核质转运增加

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The structure m~7GpppN (where N is any nucleotide), termed cap, is present at the 5' end of all eukaryotic cellular mRNAs (except organellar). The eukary- otic initiation factor 4E (eIF-4E) binds to the cap and facili- tates the formation of translation initiation complexes. eIF-4E is implicated in control of cell growth, as its overexpression causes malignant transformation of rodent cells and deregu- lates HeLa cell growth. It was suggested that overexpression of eIF-4E results in the enhanced translation of poorly trans- lated mRNAs that encode growth-promoting proteins.

机译：m〜7GpppN结构（其中N是任何核苷酸），称为帽，存在于所有真核细胞mRNA（细胞器除外）的5'端。真核起始因子4E（eIF-4E）与帽结合并促进翻译起始复合物的形成。 eIF-4E的表达过高会引起啮齿动物细胞的恶性转化并抑制HeLa细胞的生长，因此它参与了细胞生长的控制。有人认为，eIF-4E的过表达会导致编码促进生长的蛋白质的翻译较差的mRNA的翻译增强。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第3期|p.1065-1070|共6页
作者
Denis Rousseau; Roger Kaspar; Igor Rosenwald;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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4. Feature Mining and Integration for Improving the Prediction Accuracy of Translation Initiation Sites in Eukaryotic mRNAs [C] . Chuang Ma, Dao Zhou, Yanhong Zhou International Conference on Grid and Cooperative Computing; 20061021-23; Hunan(CN) . 2006

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5. Discovery, Phylogenetic Analysis, and Functional Characterization of a Unique Family of Eukaryotic Translation Initiation Factor 4E, eIF4E, From Amphidinium carterae, a Marine Dinoflagellate. [D] . Jones, Grant D. 2016

机译：发现，系统发生分析和功能特性的一个独特的真核翻译起始因子4E，eIF4E，从海洋双鞭毛虫角叉菜。
6. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. [O] . D Rousseau, R Kaspar, I Rosenwald, 1996

机译：在过度表达真核生物起始因子4E的细胞中鸟氨酸脱羧酶的翻译起始和细胞周期蛋白D1 mRNA的核质转运增加。
7. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. [O] . Rousseau, D, Kaspar, R, Rosenwald, I, 1996

机译：在过度表达真核生物起始因子4E的细胞中，鸟氨酸脱羧酶的翻译起始和细胞周期蛋白D1 mRNA的核质转运增加。
8. Studying the Role of Eukaryotic Translation Initiation Factor 4E (eIF4E) Phosphorylation by MNK1/2 Kinases in Prostate Cancer Development and Progression. [R] . Fonseca, B. 2013

机译：研究真核翻译起始因子4E（eIF4E）对mNK1 / 2激酶的磷酸化在前列腺癌发展和进展中的作用。

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E

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