Feature Mining and Integration for Improving the Prediction Accuracy of Translation Initiation Sites in Eukaryotic mRNAs

机译：特征挖掘和集成，提高真核mRNA翻译起始位点的预测准确性

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Accurate prediction of translation initiation sites (TISs) is important for the annotation of genomes.Although many methods have been proposed to solve this problem, the prediction accuracy is still limited. In this paper, the features that have been widely used for predicting TISs are further analyzed, and it is found that some features of TISs and non-TISs are heavily dependent on the C+G content of sequences around AUG codons, and some features are quite different for non-TISs located in untranslated regions and coding regions considering different reading frames. Further,the strategy of using multiple support vector machines to fully make use of the information is proposed, and a new program TISKey for the prediction of TISs is developed. Testing results on widely used dataset demonstrate that TISKey could get better prediction accuracy. TISKey can be accessed at http: //infosci. hust. edu. cn .

机译：准确预测翻译起始位点（TIS）对于基因组注释非常重要。尽管已经提出了许多解决此问题的方法，但预测准确性仍然受到限制。在本文中，进一步分析了广泛用于预测TIS的特征，发现TIS和非TIS的某些特征在很大程度上取决于AUG密码子周围序列的C + G含量，其中一些特征是考虑到不同的阅读框，位于非翻译区域和编码区域中的非TIS会有很大不同。此外，提出了使用多个支持向量机充分利用信息的策略，并开发了用于预测TIS的新程序TISKey。在广泛使用的数据集上的测试结果表明，TISKey可以获得更好的预测准确性。可以通过以下网址访问TISKey：http：// infosci。必要edu。 cn。

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来源
《International Conference on Grid and Cooperative Computing; 20061021-23; Hunan(CN)》|2006年|P.349-356|共8页
会议地点 Hunan(CN)
作者
Chuang Ma; Dao Zhou; Yanhong Zhou;
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作者单位

Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China;

Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei 43;

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正文语种 eng
中图分类计算技术、计算机技术;
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1. Distinct Structural Features ofCaprin-1 Mediate Its Interaction with G3BP-1 and Its Induction of Phosphorylation of Eukaryotic Translation Initiation Factor 2α, Entry to Cytoplasmic Stress Granules, and Selective Interaction with a Subset of mRNAs [J] . Samuel Solomon, Yaoxian Xu, Bin Wang, Molecular and Cellular Biology . 2007,第6期

机译：Caprin-1的不同结构特征介导其与G3BP-1的相互作用以及其诱导的真核翻译起始因子2α的磷酸化，进入细胞质应激颗粒以及与mRNA子集的选择性相互作用。
2. A class of edit kernels for SVMs to predict translation initiation sites in eukaryotic mRNAs [J] . Li HF, Jiang T Journal of computational biology: A journal of computational molecular cell biology . 2005,第6期

机译：一类用于SVM的编辑内核，以预测真核mRNA中的翻译起始位点
3. Similar Features in the Mechanisms of mRNA Translation Initiation in Eukaryotic and Prokaryotic Systems [J] . D.E.Andreev, I.M.Terenin, S.E.Dmitriev Molecular Biology . 2006,第4期

机译：真核和原核系统中mRNA翻译起始机制的相似特征
4. Feature Mining and Integration for Improving the Prediction Accuracy of Translation Initiation Sites in Eukaryotic mRNAs [C] . Chuang Ma, Dao Zhou, Yanhong Zhou International Conference on Grid and Cooperative Computing . 2006

机译：特征挖掘和集成，用于提高真核MRNA中翻译起始位点的预测准确性
5. Interactions of eukaryotic translation initiation factors and 3' untranslated region of barley yellow dwarf virus mRNA during protein synthesis: A study of equilibrium binding, kinetics and thermodynamics. [D] . Banerjee, Bidisha. 2014

机译：蛋白质合成过程中大麦黄矮病毒mRNA的真核翻译起始因子和3'非翻译区的相互作用：平衡结合，动力学和热力学的研究。
6. Improvement in the prediction of the translation initiation site through balancing methods inclusion of acquired knowledge and addition of features to sequences of mRNA [O] . Lívia Márcia Silva, Felipe Carvalho de Souza Teixeira, José Miguel Ortega, 2011

机译：通过平衡方法包括获得的知识并向mRNA序列添加特征来改善翻译起始位点的预测
7. Improvement in the prediction of the translation initiation site through balancing methods, inclusion of acquired knowledge and addition of features to sequences of mRNA [O] . Lívia Silva, Felipe de Souza Teixeira, José Ortega, 2011

机译：通过平衡方法，包括获得的知识并向mRNA序列添加特征来改善翻译起始位点的预测

Feature Mining and Integration for Improving the Prediction Accuracy of Translation Initiation Sites in Eukaryotic mRNAs

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