Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders

Jeremy D. Coplan; Michael W. Andrews; Leonard A. Rosenblum

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Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders

机译：暴露于早期应激源的成年非人类灵长类动物中脑脊髓液中促肾上腺皮质激素释放因子的浓度持续升高：对情绪和焦虑症的病理生理学意义

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There is increasing evidence for an impor- tant role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin- releasing factor (CRF), an endogenous neuropeptide, is the primary physiological regulator of the mammalian stress response. Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor.

机译：越来越多的证据表明不良的早期经验对成年后主要精神疾病的发展起着重要的作用。促肾上腺皮质激素释放因子（CRF）是一种内源性神经肽，是哺乳动物应激反应的主要生理调节剂。研究了成年的，暴露于不利的早期饲养条件下的婴儿的非人类灵长类动物，以确定在早期应激源后是否发生了CRF神经元系统的长期改变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1619-1623|共5页
作者
Jeremy D. Coplan; Michael W. Andrews; Leonard A. Rosenblum;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：母婴对非人类灵长类动物觅食需求的响应：应激时机对脑脊液促肾上腺皮质激素释放因子和循环糖皮质激素浓度的影响。
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机译：创伤相关视听刺激对创伤后应激障碍中脑脊液去甲肾上腺素和促肾上腺皮质激素释放激素浓度的影响。
4. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. [O] . J D Coplan, M W Andrews, L A Rosenblum, 1996

机译：暴露于早期应激源的成年非人类灵长类动物中脑脊髓液中促肾上腺皮质激素释放因子的浓度持续升高：对情绪和焦虑症的病理生理学的影响。
5. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. [O] . Coplan, J D, Andrews, M W, Rosenblum, L A, 1996

机译：暴露于早期应激源的成年非人类灵长类动物中脑脊髓液中促肾上腺皮质激素释放因子的浓度持续升高：对情绪和焦虑症的病理生理学的影响。

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders

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