Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster

Akos Szakmary; Shu-Mei Huang; David T. Chang

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Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster

机译：Rrp1转基因的过表达减少了果蝇中氧化性DNA损伤诱导的体细胞突变和重组频率

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Recombination repair protein 1 (Rrp1) in- ludes a C-terminal region homologous to several DNA repair proteins, including Escherichia coli exonuclease III and human APE, that repair oxidative and alkylation damage to DNA. The nuclease activities of Rrp1 include apurinic/apyrimidinic endonuclease, 3'-phosphodiesterase, 3'-phosphatase, and 3'- exonuclease. As shown previously, the C-terminal nuclease region of Rrp1 is sufficient to repair oxidative- and alkylation- induced DNA damage in repair-deficient E. coli mutants.

机译：重组修复蛋白1（Rrp1）的C端区域与几种DNA修复蛋白（包括大肠杆菌核酸外切酶III和人APE）同源，可修复DNA的氧化和烷基化损伤。 Rrp1的核酸酶活性包括嘌呤/嘧啶内切核酸酶，3'-磷酸二酯酶，3'-磷酸酶和3'-核酸外切酶。如前所示，Rrp1的C端核酸酶区域足以修复缺乏修复的大肠杆菌突变体中氧化和烷基化诱导的DNA损伤。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1607-1612|共6页
作者
Akos Szakmary; Shu-Mei Huang; David T. Chang;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Relationships between cisplatin-induced adducts and DNA strand-breaks, mutation and recombination in vivo in somatic cells of Drosophila melanogaster, under different conditions of nucleotide excision repair. [J] . Daniel García Sar, Leticia Aguado, María Montes Bayón, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2012,第1a2期

机译：在不同的核苷酸切除修复条件下，果蝇体内细胞中顺铂诱导的加合物与体内DNA链断裂，突变和重组之间的关系。
2. Relationships between cisplatin-induced adducts and DNA strand-breaks, mutation and recombination in vivo in somatic cells of Drosophila melanogaster, under different conditions of nucleotide excision repair. [J] . Daniel García Sar, Leticia Aguado, María Montes Bayón, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2012,第1a2期

机译：不同条件的核苷酸切除修复条件下，顺铂诱导的顺铂诱导的加铂诱导的增合剂和DNA链中的残疾，突变和重组在体内细胞中的不同条件下。
3. The mus309 mutation, defective in DNA double-strand break repair, increases the frequency of X-ray-induced somatic crossing over in Drosophila melanogaster, but the effect is not dose-rate dependent [J] . Petter Portin Open Journal of Genetics . 2012,第1期

机译：DNA双链断裂修复中存在缺陷的mus309突变增加了果蝇中X射线诱导的体细胞交叉的频率，但该效应与剂量率无关
4. Tissue culture-induced mutations and overexpression of full-length cDNAs as a tool for functional analysis of rice genes [C] . H. Hirochika, A. Miyao, M. Yamazaki, International Rice Genetics Symposium . 2007

机译：组织培养诱导的全长CDNA的突变和过度表达作为水稻基因功能分析的工具
5. EVOLUTIONARY, GENETIC, AND MOLECULAR ANALYSIS OF TRANSPOSABLE ELEMENT-INDUCED MUTATIONS IN DROSOPHILA MELANOGASTER (SELECTION, GEOTAXIS, ESTERASE-6, HYBRIDIZATION). [D] . PHILLIS, RANDALL W. 1986

机译：果蝇黑尾果中可转移元素诱导的突变的进化，遗传和分子分析（选择，地理，Esterase-6，杂交）。
6. Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster. [O] . A Szakmary, S M Huang, D T Chang, 1996

机译：Rrp1转基因的过表达减少了果蝇中氧化性DNA损伤诱导的体细胞突变和重组频率。
7. Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster. [O] . Szakmary, A, Huang, S M, Chang, D T, 1996

机译：Rrp1转基因的过表达减少了果蝇中由氧化性DNA损伤诱导的体细胞突变和重组频率。

Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster

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