The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

Robert E. Beyer; Juan Segura-Aguilar; Salvatore Di Bernardo

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The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

机译：DT-黄递酶在维持膜系统中还原型辅酶Q的抗氧化形式中的作用

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The experiments reported here were de- signed to test the hypothesis that the two-electron quinone reductase DT-diaphorase [NAD(P)H:(quinone-acceptor) ox- idoreductase, EC 1.6.99.2] functions to maintain membrane- bound coenzyme Q (CoQ) in its reduced antioxidant state, thereby providing protection from free radical damage. DT- diaphorase was isolated and purified from rat liver cytosol, and its ability to reduce several CoQ homologs incorporated into large unilamellar vesicles was demonstrated.

机译：本文报道的实验旨在检验以下假设：双电子醌还原酶DT-黄递酶[NAD（P）H :(醌-受体）氧化还原酶，EC 1.6.99.2]起到维持膜结合型辅酶功能的作用Q（CoQ）处于还原的抗氧化剂状态，从而提供了免受自由基破坏的保护。从大鼠肝细胞溶质中分离并纯化了DT-心肌黄递酶，并证明了它能够减少掺入大单层囊泡中的几种辅酶Q同源物的能力。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2528-2532|共5页
作者
Robert E. Beyer; Juan Segura-Aguilar; Salvatore Di Bernardo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. [O] . R E Beyer, J Segura-Aguilar, S Di Bernardo, 1996

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7. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. [O] . Beyer, R E, Segura-Aguilar, J, Di Bernardo, S, 1996

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The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

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