Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells

Andreas C. Haffner; Karoline Zepter; Craig A. Elmets

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Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells

机译：主要的组织相容性复合物I类分子用作将超抗原葡萄球菌肠毒素B呈递给T细胞的配体

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Superantigens, such as staphylococcal en- terotoxin B (SEB), elicit a strong proliferative response in T cells when presented in the context of major histocompatibil- ity complex (MHC) class II molecules. We observed a similar T-cell response, when MHC class II-negative epidermal cell lines were employed as antigen-presenting cells. Immunopre- cipitation studies indicated that the ligand to which SEB bound had a molecular mass of 46 kDa.

机译：当在主要组织相容性复合体（MHC）II类分子中出现时，超抗原，例如葡萄球菌肠毒素B（SEB），会在T细胞中引起强烈的增殖反应。当MHC II类阴性表皮细胞系用作抗原呈递细胞时，我们观察到了类似的T细胞反应。免疫沉淀研究表明，SEB结合的配体的分子质量为46 kDa。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3037-3042|共6页
作者
Andreas C. Haffner; Karoline Zepter; Craig A. Elmets;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. [J] . K Mehindate, J Thibodeau, M Dohlsten, The Journal of Experomental Medicine . 1995,第5期

机译：主要组织相容性复合物II类分子通过葡萄球菌肠毒素A的超交联是炎症细胞因子基因表达的必要条件。
2. T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. [J] . B Fleischer, H Schrezenmeier The Journal of Experomental Medicine . 1988,第5期

机译：金黄色葡萄球菌肠毒素刺激T细胞。对附属细胞或靶细胞的主要组织相容性复杂的II类分子的克隆变量应答和要求。
3. Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. [J] . G A van Seventer, W Newman, Y Shimizu, The Journal of Experomental Medicine . 1991,第4期

机译：通过超抗原加上主要的组织相容性复合物II类分子或CD3单克隆抗体对T细胞的刺激进行分析：通过纯化的粘附配体VCAM-1，ICAM-1（而非ELAM-1）进行共同刺激。
4. Superantigen Encephalitis in the Lewis Rat induced by Staphylococcal Enterotoxin A (SEA) [C] . Gerlach K., Emmer A., Kornhuber M. E., European Congress of Immunology . 2009

机译：用葡萄球菌肠毒素A（海）诱导的Lewis大鼠的超抗原脑炎
5. Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules [D] . Belizaire, Roger 2012

机译：加工用于主要组织相容性复合体I类和II类分子的外源母鸡蛋白溶菌酶的加工
6. Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells. [O] . A C Häffner, K Zepter, C A Elmets 1996

机译：主要的组织相容性复合物I类分子用作将超抗原葡萄球菌肠毒素B呈递给T细胞的配体。
7. Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells. [O] . Häffner, A C, Zepter, K, Elmets, C A 1996

机译：主要的组织相容性复合物I类分子用作将超抗原葡萄球菌肠毒素B呈递给T细胞的配体。
8. Toxicity of Staphylococcal Enterotoxins Potentiated by Lipopolysaccharide: MajorHistocompatibility Complex Class II Molecule Dependency and Cytokine Release [R] . Stiles, B. G., Bavari, S., Krakauer, T., 1993

机译：脂多糖增强金黄色葡萄球菌肠毒素的毒性：主要的相容性复合物II类分子依赖性和细胞因子释放

Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells

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