Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

Jeffrey M. Arbeit; Peter M. Howley; Douglas Hanahan

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Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

机译：慢性雌激素诱导的人乳头瘤病毒16型转基因小鼠的宫颈和阴道鳞状癌变

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High-risk human papillomaviruses (HPVs), including type 16, have been identified as factors in cervical carcinogenesis. However, the presence and expression of the virus per se appear to be insufficient for carcinogenesis. Rather, cofactors most likely are necessary in addition to viral gene expression to initiate neoplasia. One candidate cofactor is prolonged exposure to sex hormones.

机译：高危型人乳头瘤病毒（HPV）（包括16型）已被确定为宫颈癌发生的因素。然而，病毒本身的存在和表达似乎不足以致癌。而是，除了病毒基因表达以外，最有可能需要辅因子来启动瘤形成。一种候选辅助因子是长期暴露于性激素。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2930-2935|共6页
作者
Jeffrey M. Arbeit; Peter M. Howley; Douglas Hanahan;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice [J] . DepartamentodeGen茅ticayBiolog铆aMolecularCentrodeInvestigaci贸nydeEstudiosAvanzadosdelInstitutoPolit, LaboratoriodeBiolog铆aMoleculardelC谩ncerUnidaddeInvestigaci贸n, DepartmentofOncologyLombardiComprehensiveCancerCenter, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2015,第1a2期

机译：人类乳头瘤病毒16型E7癌蛋白上调宫颈癌细胞系和K14E7转基因小鼠的视黄酸受体β表达
2. Hypoxia-Inducible Factor-1 Facilitates Cervical Cancer Progression in Human Papillomavirus Type 16 Transgenic Mice [J] . Zhi Hong Lu Jason D. Wright Brian Belt Robert D. Cardiff and Jeffrey M. Arbeit American Journal of Pathology . 2007,第2期

机译：低氧诱导因子1促进人类乳头瘤病毒16型转基因小鼠宫颈癌的进展。
3. Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice. [J] . Lu ZH, Wright JD, Belt B, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2007,第2期

机译：低氧诱导因子1促进人乳头瘤病毒16型转基因小鼠的宫颈癌进展。
4. Phylogenetic Study of L1 Protein Human Papillomavirus Type 16 from Cervical Cancer Patients in Bandung [C] . Fitri Rahmi Fadhilah, Ani Melani Maskoen, Edhyana Sahiratmadja, Molecular Medicine TRI-CON. . 2014

机译：L1蛋白人乳头瘤病毒16型来自宫颈癌患者L1蛋白人乳头瘤病毒的系统发育研究
5. Mechanism of Action of Human Papillomavirus Type 16 E7 in Human Papillomavirus-associated Carcinogenesis [D] . Shin, Myeong-Kyun 2012

机译：人乳头瘤病毒16 E7在人乳头瘤病毒相关致癌作用中的作用机制。
6. Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. [O] . J M Arbeit, P M Howley, D Hanahan 1996

机译：慢性雌激素诱导的人乳头瘤病毒16型转基因小鼠的宫颈和阴道鳞状癌变。
7. Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. [O] . Arbeit, J M, Howley, P M, Hanahan, D 1996

机译：慢性雌激素诱导的人乳头瘤病毒16型转基因小鼠的宫颈和阴道鳞状癌变。

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

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