Enhanced pathologic properties of Dutch-type mutant amyloid β -protein

Judianne Davis; William E. Van Nostrand

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Enhanced pathologic properties of Dutch-type mutant amyloid β -protein

机译：荷兰型突变淀粉样β蛋白的增强病理学特性

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In the present study, we show that the HCHWA-D mutation converts the normally nonpathologic Aβ_1-40 into a highly pathologic form of the peptide for cultured human leptomeningeal smooth muscle cells. These findings suggest that these altered functional properties of HCHWA-D mutated Aβmay contribute to the early and often severe cerebrovascular pathology that is the hallmark of this disorder.

机译：在本研究中，我们显示了HCHWA-D突变将正常的非病理性Aβ_1-40转化为用于培养的人类软脑膜平滑肌细胞的肽的高度病理性形式。这些发现表明，HCHWA-D突变的Aβ的这些功能特性的改变可能有助于早期且通常是严重的脑血管病理，这是该疾病的标志。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2996-3000|共5页
作者
Judianne Davis; William E. Van Nostrand;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant. [J] . Eisenhauer PB, Johnson RJ, Wells JM, Journal of Neuroscience Research . 2000,第6期

机译：培养的人血脑屏障内皮细胞中各种淀粉样β肽物种的毒性：荷兰型突变体的毒性增加。
2. Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. [J] . Zhang HY, Yan H, Tang XC Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2004,第1a2期

机译：石杉碱甲提高了脑室内β-淀粉样蛋白-（1-40）注入的大鼠和人胚肾293瑞典突变细胞中淀粉样蛋白前体蛋白和蛋白激酶C-α的分泌水平。
3. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology [J] . Arrozi Aslina Pahrudin, Shukri Siti Nur Syazwani, Ngah Wan Zurinah Wan, Applied biochemistry and biotechnology, Part A. enzyme engineering and biotechnology . 2017,第3期

机译：淀粉样蛋白前体蛋白的表达及分泌的淀粉样蛋白β22中的淀粉样蛋白β20与APP基因的野生型细胞中淀粉样蛋白β40与APP基因的双突变形式的淀粉样蛋白β40的比例进行评价，用于研究Alzheimer疾病的研究病理
4. WILD TYPE TRANSTHYRET1N-DER1VED SENILE SYSTEMIC AMYLO1DOSIS WITH LIMITED PROTEOLYTIC DIGESTION OF THE MONOMER: CLINICO-PATHOLOGIC STUDIES WITH DNA AND AMYLOID PROTEIN CHARACTERIZATION [C] . Maria M. Picken, Fred Leya, Roger N. Picke International Symposium on Amyloidosis . 2005

机译：野生型Transthyret1N-Der1ved老年全身淀粉，具有有限的单体蛋白水解消化：临床病理研究与DNA和淀粉样蛋白表征
5. beta-Endorphin inhibits the expression of amyloid precursor protein in SK-N-SH neuroblastoma cells expressing high levels of mutant amyloid precursor protein. [D] . Boggeti, Renuka. 2012

机译：β-内啡肽抑制表达高水平突变淀粉样蛋白前体蛋白的SK-N-SH神经母细胞瘤细胞中淀粉样蛋白前体蛋白的表达。
6. Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein. [O] . J Davis, W E Van Nostrand 1996

机译：荷兰型突变淀粉样β蛋白的增强的病理特性。
7. Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein. [O] . Davis, J, Van Nostrand, W E 1996

机译：荷兰型突变淀粉样β蛋白的增强的病理特性。

Enhanced pathologic properties of Dutch-type mutant amyloid β -protein

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