A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

John P. OBryan; Zhou Songyang; Lewis Cantley

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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

机译：具有保守的Src同源性2和磷酸酪氨酸结合结构域的哺乳动物衔接蛋白与Shc相关并且在脑中特异性表达

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The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-rec- ognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Phosphorylation of human ShcA at Tyr-317 within its central (CH1) region induces binding to the Grb2 SH2 domain and is thereby implicated in activation of the Ras pathway.

机译：Shc衔接子蛋白（以下称为ShcA）具有两个不同的磷酸酪氨酸识别模块，一个C端Src同源2（SH2）域和一个N端磷酸酪氨酸结合（PTB）域，并且自身被磷酸化酪氨酸响应许多细胞外信号。人ShcA在其中央（CH1）区域内的Tyr-317处的磷酸化诱导与Grb2 SH2结构域的结合，从而与Ras途径的激活有关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2729-2734|共6页
作者
John P. OBryan; Zhou Songyang; Lewis Cantley;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC). [J] . Taouis M, Dupont J, Gillet A, Molecular and Cellular Endocrinology . 1998,第2期

机译：肝癌细胞系中的胰岛素受体底物1反义表达减少细胞增殖并诱导Src同源2域和胶原蛋白（SHC）的过表达。
2. Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. [J] . Li Y, He X, Schembri King-J, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第10期

机译：人Lnk的克隆和表征，Lnk是一种具有pleckstrin同源性和Src同源性2结构域的衔接蛋白，可以抑制T细胞活化。
3. Cloning and Characterization of Human Lnk, an Adaptor Protein with Pleckstrin Homology and Src Homology 2 Domains that Can Inhibit T Cell Activation [J] . Yijin Li, Xiaoqing He, Josephine Schembri-King, The journal of immunology . 2000,第10期

机译：人Lnk的克隆和表征，一种具有Pleckstrin同源性和Src同源性2域的抑制蛋白，可以抑制T细胞活化
4. Gene expression profiling of mouse postnatal cerebellar develoment adaptor-tagged competitive PCR and its application to the mammalian nervous system [C] . Kikuya Kato Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：小鼠产后小脑缺乏适配器标记竞争性PCR的基因表达分析及其在哺乳动物神经系统中的应用
5. Src-like adaptor protein: A molecule that regulates TCR/CD3 expression by adapting the E3 ubiquitin ligasec-Cbl to the TCR/CD3 complex. [D] . Myers, Margaret D. 2005

机译：Src样衔接蛋白：通过使E3泛素ligasec-Cbl适应TCR / CD3复合体来调节TCR / CD3表达的分子。
6. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. [O] . J P OBryan, Z Songyang, L Cantley, 1996

机译：具有保守的Src同源性2和磷酸酪氨酸结合结构域的哺乳动物衔接蛋白与Shc有关并在大脑中特异性表达。
7. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. [O] . O'Bryan, J P, Songyang, Z, Cantley, L, 1996

机译：具有保守的Src同源性2和磷酸酪氨酸结合结构域的哺乳动物衔接蛋白与Shc有关，并在大脑中特异性表达。

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

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