Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3β in brain

Minako Hoshi; Akihiko Takashima; Kaori Noguchi

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Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3β in brain

机译：tau蛋白激酶I /糖原合酶激酶3β对脑线粒体丙酮酸脱氢酶活性的调节

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According to the amyloid hypothesis for the pathogenesis of Alzheimer disease, β-amyloid peptide (βA) directly affects neurons, leading to neurodegeneration and tau phosphorylation. In rat hippocampal culture, βA exposure activates tau protein kinase I/glycogen synthase kinase 3β (TPKI/GSK-3β), which phosphorylates tau protein into Alz- heimer disease-like forms, resulting in neuronal death.

机译：根据阿尔茨海默病发病机理的淀粉样假说，β-淀粉样肽（βA）直接影响神经元，导致神经变性和tau磷酸化。在大鼠海马培养物中，βA暴露会激活tau蛋白激酶I /糖原合酶激酶3β（TPKI /GSK-3β），该蛋白将tau蛋白磷酸化为阿兹海默氏病样形式，导致神经元死亡。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2719-2723|共5页
作者
Minako Hoshi; Akihiko Takashima; Kaori Noguchi;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Distribution of tau protein kinase I/glycogen synthase kinase-3beta, phosphatases 2A and 2B, and phosphorylated tau in the developing rat brain. [J] . Takahashi M, Tomizawa K, Ishiguro K Brain research . 2000,第1a2期

机译：tau蛋白激酶I /糖原合酶激酶3β，磷酸酶2A和2B以及磷酸化tau在发育中的大鼠脑中的分布。
2. Glycogen Synthase Kinase-3 beta 2 Has Lower Phosphorylation Activity to Tau than Glycogen Synthase Kinase-3 beta 1 [J] . Saeki K, Machida M, Kinoshita Y, Biological & pharmaceutical bulletin . 2011,第1期

机译：糖原合酶激酶3 beta 2比糖原合酶激酶3 beta 1具有更低的磷酸化Tau活性。
3. Long-term regulation of pyruvate dehydrogenase complex. Evidence that kinase-activator protein (KAP) is free pyruvate dehydrogenase kinase [J] . B S Jones, S J Yeaman The biochemical journal . 1991,第3期

机译：丙酮酸脱氢酶复合物的长期调节。激酶激活蛋白（KAP）是游离丙酮酸脱氢酶激酶的证据
4. Lithium inhibits tau hyperphosphorylation mediated by glycogen synthase kinase 3 and protein phosphatase 2A in the hippocampus of eight week and twelve month old starved mice [C] . Xiong, S., Lovell, Workshop on Macro, Trace and Ultratrace Elements; 20040924-25; Jena(DE) . 2004

机译：锂抑制八周和十二个月大饥饿小鼠海马中糖原合酶激酶3和蛋白磷酸酶2A介导的tau过度磷酸化
5. Regulation of peroxisome proliferator -activated receptor alpha activity via cross -talk with glycogen synthase kinase -3 [D] . Burns, Katherine Anne 2007

机译：通过与糖原合酶激酶-3的串扰来调节过氧化物酶体增殖物激活的受体α的活性
6. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. [O] . M Hoshi, A Takashima, K Noguchi, 1996

机译：大脑中tau蛋白激酶I /糖原合酶激酶3beta对线粒体丙酮酸脱氢酶活性的调节。
7. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. [O] . Hoshi, M, Takashima, A, Noguchi, K, 1996

机译：大脑中tau蛋白激酶I /糖原合酶激酶3beta对线粒体丙酮酸脱氢酶活性的调节。

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3β in brain

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