cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

Karlene A. Cimprich; Tae Bum Shin; Curtis T. Keith

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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

机译：候选人类细胞周期检查点蛋白的cDNA克隆和基因定位

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A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Other members include Mei-41 (Drosophila melanogaster), Mec1p (Saccharomyces cer- evisiae), and Rad3 (Schizosaccharomyces pombe), which are required for the S and G_2/M checkpoints, as well as FRAP (Homo sapiens) and Tor1/2p (S. cerevisiae), which are involved in a rapamycin-sensitive pathway leading to G_1 cell cycle progression.

机译：最近已经确定了涉及细胞周期进程，DNA重组和DNA损伤检测的蛋白质家族。该家族的成员之一，人ATM，在共济失调性毛细血管扩张症患者的细胞中存在缺陷，并参与细胞对受损DNA的检测和反应。其他成员包括Mei-41（果蝇（Drosophila melanogaster），Mac1p（酿酒酵母）和Rad3（Schizosaccharomyces pombe），它们是S和G_2 / M检查点以及FRAP（智人）和Tor1 / 2p所必需的。（S. cerevisiae），其参与雷帕霉素敏感性途径导致G_1细胞周期进程。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2850-2855|共6页
作者
Karlene A. Cimprich; Tae Bum Shin; Curtis T. Keith;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. [O] . K A Cimprich, T B Shin, C T Keith, 1996

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7. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. [O] . Cimprich, K A, Shin, T B, Keith, C T, 1996

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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

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