The brain-specific activator p35 allows Cdk5 to escape inhibition by p27~Kip1 in neurons

Mong-Hong Lee; Margareta Nikolic; Carlos A. Baptista

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The brain-specific activator p35 allows Cdk5 to escape inhibition by p27~Kip1 in neurons

机译：脑特异性激活剂p35允许Cdk5逃避神经元中p27〜Kip1的抑制

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Cell cycle withdrawal in postmitotic cells involves cyclin-dependent kinase (Cdk) inhibitors that repress cell cycle Cdk activity. During mouse neurogenesis, cortical postmitotic neurons are shown here to accumulate high levels of the p27 Cdk inhibitor compared with their progenitor neuroblasts. Elevated p27 levels in staged embryo brain extracts correlate with p27 binding to Cdk2, and Cdk2 inac- tivation.

机译：有丝分裂后细胞中的细胞周期退出涉及抑制细胞周期Cdk活性的细胞周期蛋白依赖性激酶（Cdk）抑制剂。在小鼠神经发生过程中，此处显示皮质有丝分裂后神经元与其祖细胞成神经细胞相比，积累了高水平的p27 Cdk抑制剂。分阶段胚胎脑提取物中p27的水平升高与p27与Cdk2的结合以及Cdk2的激活有关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3259-3263|共5页
作者
Mong-Hong Lee; Margareta Nikolic; Carlos A. Baptista;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity [J] . BkB., ZhengY.-L., ShuklaV., Journal of Alzheimer's disease: JAD . 2014,第4期

机译：TFP5是一种从p35（一种Cdk5神经元激活剂）衍生的肽，可从糖毒性中拯救皮质神经元
2. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons. [J] . Kerokoski P, Suuronen T, Salminen A, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2004,第2期

机译：N-甲基-D-天门冬氨酸（NMDA）和非NMDA受体均介导谷氨酸诱导的大鼠海马神经元细胞周期蛋白依赖性激酶5（cdk5）激活剂p35的裂解。
3. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. [J] . Harada T, Morooka T, Ogawa S, Nature cell biology . 2001,第5期

机译：ERK通过诱导Egr1来诱导p35（一种Cdk5的神经元特异性激活剂）。
4. The Development of p27~(kip1) Nanoliposome Gene Delivery System and Its Growth Inhibition Effects on Human Lung Caner Cells [C] . Hongwei Zhang, Xun Sun, Ling Zhang, Controlled Release Society Annual Meeting and Exposition . 2007

机译：p27〜（kip1）纳米脂质体基因传递系统的开发及其对人肺癌细胞的生长抑制作用
5. cAMP and polyamines overcome inhibition by MAG by activating Cdk5 via increased expression of p35 regulated by activation of eIF5A. [D] . He, Huifang. 2010

机译：cAMP和多胺通过激活ed5A调节的p35表达的增加来激活Cdk5，从而克服了MAG的抑制作用。
6. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. [O] . M H Lee, M Nikolic, C A Baptista, 1996

机译：脑特异性激活剂p35允许Cdk5逃避神经元中p27Kip1的抑制。
7. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. [O] . Lee, M H, Nikolic, M, Baptista, C A, 1996

机译：脑特异性激活剂p35允许Cdk5逃避神经元中p27Kip1的抑制。

The brain-specific activator p35 allows Cdk5 to escape inhibition by p27~Kip1 in neurons

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