Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation

Stefan Wolfl; Camilo Martinez; Alexander Rich

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Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation

机译：NPLC细胞中人类促肾上腺皮质激素释放激素基因的转录与Z-DNA的形成有关

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The intron of the corticotropin-releasing hormone (corticoliberin; CRH) gene contains a sequence of over 100 bp of alternating purine/pyrimidine residues. We have used binding of a Z-DNA-specific antibody in metabol- ically active, permeabilized nuclei to study the formation of Z-DNA in this sequence at various levels of transcription. In the NPLC human primary liver carcinoma cell line, activation of cAMP-dependent pathways increased the level of transcrip- tion, while adding glucocorticoids inhibited transcription of the CRH gene.

机译：促肾上腺皮质激素释放激素（corticoliberin； CRH）基因的内含子包含一个超过100 bp的嘌呤/嘧啶交替残基序列。我们已经使用了Z-DNA特异性抗体在具有代谢活性的，可透化的细胞核中的结合，来研究该序列在各种转录水平下Z-DNA的形成。在NPLC人原发性肝癌细胞系中，依赖cAMP的途径的激活增加了转录水平，同时添加糖皮质激素抑制了CRH基因的转录。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3664-3668|共5页
作者
Stefan Wolfl; Camilo Martinez; Alexander Rich;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. The transcription of corticotropin-releasing hormone in human endometrial cells is regulated by cytokines. [J] . Makrigiannakis A, Margioris AN, Zoumakis E, Neuroendocrinology: International Journal for Basic and Clinical Studies on Neuroendocrine Relationships . 1999,第6期

机译：人子宫内膜细胞中促肾上腺皮质激素释放激素的转录受细胞因子调节。
2. Adolescent;AduBiological Markers;Cells, Cultured;Cervix Uteri;Corticotropin-Releasing Hormone;Female;Fibroblasts;Gene Expression Regulation, Enzymologic;Humans;Interleukin-8;Matrix Metalloproteinases;Pregnancy;Premature Birth;RNA, Messenger;Term Birth [J] . AIDS care. . 2009,第6期

机译：青春期;成人;生物学标记物;培养的细胞;子宫子宫;促肾上腺皮质激素释放激素;女性;成纤维细胞;基因表达调控，酶学;人类;白介素-8;基质金属蛋白酶;妊娠;早产; RNA，信使;足月出生
3. Regulation of the promoter of the human corticotropin-releasing hormone gene in transfected human endometrial cells. [J] . Makrigiannakis A, Zoumakis E, Margioris AN, Neuroendocrinology: International Journal for Basic and Clinical Studies on Neuroendocrine Relationships . 1996,第2期

机译：人促肾上腺皮质激素释放激素基因的启动子在转染的人子宫内膜细胞中的调节。
4. "Promoter Array" Studies Identify Cohorts of Genes Directly Regulated by Methylation, Copy Number Change, or Transcription Factor Binding in Human Cancer Cells [C] . YIPENG WANG, JUN HAYAKAWA, FRED LONG, NIH Symposium on Therapeutic Oligonucleotides . 2005

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5. Transcriptional regulation of prostate specific antigen and human osteocalcin genes in hormone refractory human prostate cancer cells. [D] . Yeung, Fan. 2001

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6. Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. [O] . S Wölfl, C Martinez, A Rich, 1996

机译：NPLC细胞中人类促肾上腺皮质激素释放激素基因的转录与Z-DNA的形成有关。
7. Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. [O] . Wölfl, S, Martinez, C, Rich, A, 1996

机译：NPLC细胞中人类促肾上腺皮质激素释放激素基因的转录与Z-DNA的形成有关。

Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation

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