Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

Tooru M. Mizuno; Hugo Bergen; Toshiya Funabashi

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

【24h】

Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

机译：肥胖的基因表达：通过在瘦肉小鼠中禁食和胰岛素和葡萄糖刺激来减少肥胖，并且在获得性（饮食诱导）和遗传性（黄刺）肥胖中持续升高

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Mutations in the obese (ob) gene lead to obesity. This gene has been recently cloned, but the factors regulating its expression have not been elucidated. To address the regulation of the ob gene with regard to body weight and nutritional factors, Northern blot analysis was used to assess ob mRNA in adipose tissue from mice [lean, obese due to diet, or genetically (yellow agouti) obese] under different nutri- tional conditions. ob mRNA was elevated in both forms of obesity, compared to lean controls, correlated with elevations in plasma insulin and body weight, but not plasma glucose.

机译：肥胖（ob）基因突变会导致肥胖。最近已经克隆了该基因，但尚未阐明调节其表达的因素。为了解决ob基因在体重和营养因素方面的调节，使用Northern印迹分析来评估小鼠在不同营养下的脂肪组织中的ob mRNA的水平[瘦，因饮食而肥胖或遗传性（黄色刺豚鼠）肥胖] -国情。与瘦对照相比，两种肥胖形式的ob mRNA均升高，与血浆胰岛素和体重的升高相关，但与血浆葡萄糖的升高无关。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3434-3438|共5页
作者
Tooru M. Mizuno; Hugo Bergen; Toshiya Funabashi;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. The release of insulin from pancreatic islets of lean and obese mice stimulated in vitro by pituitary glands from obese mice and by high glucose concentrations [J] . Beloff-Chain Anne, Hawthorn Janet FEBS Letters . 1976,第1期

机译：肥胖小鼠的垂体和高葡萄糖浓度刺激的瘦小鼠和肥胖小鼠胰岛中胰岛素的释放
2. Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice [J] . Gotthardt Juliet D., Verpeut Jessica L., Yeomans Bryn L., Endocrinology . 2016,第2期

机译：间歇性禁食可促进脂肪减少，并保持瘦体质量，下丘脑去甲肾上腺素含量增加和饮食诱导的肥胖雄性小鼠神经肽Y基因表达增加。
3. Glucose Metabolism and Insulin Sensitivity in Transgenic Mice Overexpressing Leptin With Lethal Yellow Agouti Mutation Usefulness of Leptin for the Treatment of Obesity-Associated Diabetes [J] . Hiroaki Masuzaki, Yoshihiro Ogawa, Megumi Aizawa-Abe Diabetes . 1999,第8期

机译：过量表达瘦素的致死性黄色致痛突变的转基因小鼠的葡萄糖代谢和胰岛素敏感性瘦素在治疗肥胖相关糖尿病中的作用
4. Simulating and predicting glucose response in lean and obese mice [C] . Brenner M., Kwon G., Lee H.F., 2014 40th Annual Northeast Bioengineering Conference . 2014

机译：模拟和预测肥胖和肥胖小鼠的葡萄糖反应
5. The effects of genetic background and adrenalectomy on the obese phenotype and hypothalamic neuropeptide expression in corpulent (cp) rats and agouti (Avy) mice. [D] . Brown, Lynda Marie. 2003

机译：遗传背景和肾上腺切除术对肥胖（cp）大鼠和刺豚鼠（Avy）小鼠肥胖表型和下丘脑神经肽表达的影响。
6. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. [O] . T M Mizuno, H Bergen, T Funabashi, 1996

机译：肥胖的基因表达：瘦小鼠的禁食和胰岛素和葡萄糖刺激使其减少以及获得性（饮食诱发）和遗传性（黄色刺鼠）肥胖持续升高。
7. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. [O] . Mizuno, T M, Bergen, H, Funabashi, T, 1996

机译：肥胖的基因表达：瘦小鼠的禁食和胰岛素和葡萄糖刺激使其减少，以及获得性（饮食诱发）和遗传性（黄色刺鼠）肥胖持续升高。
8. Molecular analysis of the mouse agouti gene and the role of dominant agouti-locus mutations in obesity and insulin resistance [R] . Klebig, M. L., Woychik, R. P., Wilkinson, J. E. 1994

机译：小鼠刺豚鼠基因的分子分析和优势刺激基因座突变在肥胖和胰岛素抵抗中的作用

Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

摘要

著录项

相似文献

相关主题

期刊订阅