A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA

Jason G. Lewis; Kuei-Ying Lin; Avinash Kothavale

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A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA

机译：用于反义寡聚脱氧核苷酸和质粒DNA细胞递送的抗血清cytofectin

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Development of antisense technology has fo- cused in part on creating improved methods for delivering oligodeoxynucleotides (ODNs) to cells. In this report, we describe a cationic lipid that, when formulated with the fusogenic lipid dioleoylphosphatidylethanolamine, greatly im- proves the cellular uptake properties of antisense ODNs, as well as plasmid DNA.

机译：反义技术的发展部分集中在创建将寡聚脱氧核苷酸（ODN）传递至细胞的改良方法上。在本报告中，我们描述了一种阳离子脂质，当与融合脂质二油酰基磷脂酰乙醇胺一起配制时，可大大提高反义ODN和质粒DNA的细胞摄取特性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3176-3181|共6页
作者
Jason G. Lewis; Kuei-Ying Lin; Avinash Kothavale;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. A Calcium Phosphate Nanoparticle-Based Biocarrier for Efficient Cellular Delivery of Antisense Oligodeoxynucleotides [J] . Shenglei Hou, Hongmei Ma, Yuxuan Ji ACS applied materials & interfaces . 2013,第3期

机译：一种基于磷酸钙纳米颗粒的生物载体，可有效地反义寡核苷酸的细胞递送。
2. In vitro release characteristics and cellular uptake of poly(D,L-lactic-co-glycolic acid) nanoparticles for topical delivery of antisense oligodeoxynucleotides. [J] . Chen YS, Alany RG, Young SA, Drug delivery. . 2011,第7期

机译：聚（D，L-乳酸-乙醇酸共聚物）纳米粒子的体外释放特性和细胞摄取，用于局部递送反义寡聚脱氧核苷酸。
3. In vitro release characteristics and cellular uptake of poly(D,L-lactic-co-glycolic acid) nanoparticles for topical delivery of antisense oligodeoxynucleotides [J] . Ying-Shan Chen, Raid G. Alany, Simon A. Young, Drug delivery. . 2011,第7期

机译：聚（D，L-乳酸-乙醇酸共聚物）纳米粒的体外释放特性和细胞吸收，用于局部递送反义寡聚脱氧核苷酸
4. Studies on uptake and sub-cellular trafficking of antisense oligodeoxynucleotides using self-assembled cationic liposomes as delivery systems [C] . Aminul Islam, Kevin S.J. Thompson, Sheila L. Handley, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：以自组装阳离子脂质体为递送系统研究反义寡脱氧核苷酸的摄取和亚细胞运输
5. Targeting DNA expression and hybridization with light: Application to plasmid transfections and antisense oligodeoxynucleotides. [D] . Monroe, William Todd. 2001

机译：靶向DNA表达和光杂交：应用于质粒转染和反义寡脱氧核苷酸。
6. A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. [O] . J G Lewis, K Y Lin, A Kothavale, 1996

机译：一种抗血清寡糖可用于细胞反义寡核苷酸和质粒DNA的递送。
7. A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. [O] . Lewis, J G, Lin, K Y, Kothavale, A, 1996

机译：一种抗血清寡糖，可用于细胞反义寡核苷酸和质粒DNA的递送。

A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA

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