Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

Rui-Ming Xu; Gilles Carmel; Jeff Kuret

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Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

机译：蛋白质激酶抑制剂异喹啉磺酰胺家族选择性的结构基础

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A large family of isoquinoline sulfonamide compounds inhibits protein kinases by competing with aden- osine triphosphates (ATP), yet interferes little with the activ- ity of other ATP-using enzymes such as ATPases and adenyl- ate cyclases. One such compound, N-(2-aminoethyl)-5- chloroisoquinoline-8-sulfonamide (CKI7), is selective for casein kinase-1 isolated from a variety of sources.

机译：一大批异喹啉磺酰胺化合物通过与腺苷三磷酸（ATP）竞争来抑制蛋白激酶，而对其他使用ATP的酶（例如ATPase和腺苷酸环化酶）的活性影响很小。一种这样的化合物，N-（2-氨基乙基）-5-氯异喹啉-8-磺酰胺（CKI7），对于从多种来源分离的酪蛋白激酶-1具有选择性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6308-6313|共6页
作者
Rui-Ming Xu; Gilles Carmel; Jeff Kuret;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B [J] . Ian Collins, John Caldwell, Tatiana Fonseca, Bioorganic and Medicinal Chemistry . 2006,第4期

机译：蛋白激酶B的异喹啉-5-磺酰胺抑制剂的基于结构的设计
3. Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of c-fos mRNA by the protein kinase A inhibitor N-(2-(p-bromocinnamylamino)ethyl)-5-isoquinoline sulfonamide. [J] . Huang YT, Lin JK, Lee MT Biochemical Pharmacology . 1999,第10期

机译：蛋白激酶A抑制剂N-（2-（对-溴肉桂酸氨基）乙基）-5-异喹啉磺酰胺抑制12-O-十四烷酰phorbol-13-乙酸盐诱导c-fos mRNA。
4. The Effects of Go 6983 and a Selective Protein Kinase C beta II Peptide Inhibitor on Local Hyperglycemia-Indnced Leukocyte-Endothelial Interactions [C] . Qian Chen, Edward Iames, Daniel Torino American Peptide Symposium . 2011

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5. Crystal structure of mammalian casein kinase I exhibits basis for phosphate recognition by a protein kinase family. [D] . Longenecker, Kenton Lamar. 1997

机译：哺乳动物酪蛋白激酶I的晶体结构显示了蛋白激酶家族识别磷酸盐的基础。
6. Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. [O] . R M Xu, G Carmel, J Kuret, 1996

机译：蛋白激酶抑制剂异喹啉磺酰胺家族选择性的结构基础。
7. Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. [O] . Xu, R M, Carmel, G, Kuret, J, 1996

机译：蛋白激酶抑制剂异喹啉磺酰胺家族选择性的结构基础。

Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

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