Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers

Arun J. Nataraj; Homer S. Black; Honnavara N. Ananthaswamy

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Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers

机译：在8-甲氧基补骨脂素和紫外线A（PUVA）诱导的小鼠皮肤癌中DNA交联位点的标志性p53突变

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A combination of psoralen and ultraviolet A radiation (PUVA) is widely used in the treatment of psoriasis. However, PUVA treatment increases the risk of developing skin cancer in psoriasis patients and induces skin cancer in mice. Since the DNA damage induced by PUVA is quite different from that induced by UV, we investigated whether PUVA-induced mouse skin cancers display carcinogen- specific mutations in the p53 tumor suppressor gene.

机译：补骨脂素和紫外线A辐射（PUVA）的组合被广泛用于治疗牛皮癣。然而，PUVA治疗增加了牛皮癣患者发生皮肤癌的风险并在小鼠中诱发皮肤癌。由于PUVA诱导的DNA损伤与UV诱导的DNA损伤完全不同，因此我们研究了PUVA诱导的小鼠皮肤癌在p53抑癌基因中是否显示致癌物特异性突变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第15期|p.7961-7965|共5页
作者
Arun J. Nataraj; Homer S. Black; Honnavara N. Ananthaswamy;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients. [J] . Monti P, Inga A, Aprile A, Mutagenesis . 2000,第2期

机译：由8-甲氧基补骨脂素加UVA（PUVA）实验诱导的p53突变不同于在PUVA治疗的患者的人类皮肤癌中发现的p53突变。
2. Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors. [J] . Badgwell DB, Walker CM, Baker WT, Molecular Carcinogenesis . 2004,第3期

机译：乙醇和芦荟大黄素会改变紫外线诱导的鼠皮肤肿瘤中的p53突变谱。
3. Inhibition of UV-induced p53 mutations and skin cancers by sunscreens: implication for skin cancer prevention. [J] . Ananthaswamy HN, Ullrich SE, Kripke ML Experimental dermatology . 2002,第Suppla1期

机译：防晒霜可抑制紫外线诱导的p53突变和皮肤癌：对预防皮肤癌具有重要意义。
4. DNA Array with nanoparticle probes for the detection of P53 mutations of Lung Cancer [C] . Ma Liang, rnGuo Qinggong The 6th China international conference on nanoscience and technology . 2007

机译：带有纳米粒子探针的DNA阵列用于检测肺癌的P53突变
5. K-ras andp53 mutations and DNA repair genes polymorphisms as biomarkers for lung cancer. [D] . Gao, Weimin. 2003

机译：K-ras和p53突变和DNA修复基因多态性作为肺癌的生物标记。
6. Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. [O] . A J Nataraj, H S Black, H N Ananthaswamy 1996

机译：在8-甲氧基补骨脂素和紫外线A（PUVA）诱导的鼠类皮肤癌中DNA交联位点的特征性p53突变。
7. Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. [O] . Nataraj, A J, Black, H S, Ananthaswamy, H N 1996

机译：在8-甲氧基补骨脂素和紫外线A（PUVA）诱导的鼠类皮肤癌中DNA交联位点的特征性p53突变。

Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers

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