Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila

David A. GdulaTatiana I. Gerasimova; Victor G. Corces

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Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila

机译：果蝇吉普赛染色质绝缘子的遗传和分子分析

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Boundary or insulator elements set up inde- pendent territories of gene activity by establishing higher order domains of chromatin structure. The gypsy retrotrans- poson of Drosophila contains an insulator element that re- presses enhancer-promoter interactions and is responsible for the mutant phenotypes caused by insertion of this element. The gypsy insulator inhibits the interaction of promoter-distal enhancers with the transcription complex without affecting the functionality of promoter-proximal enhancers; in addi- tion, these sequences can buffer a transgene from chromo- somal position effects.

机译：边界或绝缘子元件通过建立染色质结构的更高阶域来建立基因活性的独立区域。果蝇的吉普赛逆转录转座子包含一个绝缘子元件，该元件可抑制增强子-启动子的相互作用，并负责插入该元件而引起的突变表型。吉普赛绝缘子抑制启动子-远端增强子与转录复合物的相互作用，而不会影响启动子-近端增强子的功能。另外，这些序列可以缓冲染色体位置效应引起的转基因。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9378-9383|共6页
作者
David A. GdulaTatiana I. Gerasimova; Victor G. Corces;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. Individual effects of the copia and gypsy enhancer and insulator on chromatin marks, eRNA synthesis, and binding of insulator proteins in transfected genetic constructs [J] . Fedoseeva Daria M., Kretova Olga V., Gorbacheva Maria A., Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2018,第期

机译：Copia和Gypsy增强剂和绝缘体对染色质标记，erna合成和绝缘子蛋白结合在转染的遗传构建中的单独作用
2. The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila (vol 132, jcs226092, 2019) [J] . Bag Indira, Dale Ryan K., Palmer Cameron, Journal of Cell Science . 2019,第6期

机译：锌手指蛋白夹具在果蝇（Vol 132，JCS226092,2019）中促进吉普赛染色质绝缘体功能
3. The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila [J] . Bag Indira, Dale Ryan K., Palmer Cameron, Journal of Cell Science . 2019,第5期

机译：锌 - 手指蛋白夹具在果蝇中促进吉普赛染色质绝缘体功能
4. Biological discoveries with biomolecular sequence analysis. Case studies: posttranslational modifications of proteins and complexes for chromatin organization [C] . Eisenhaber, F., Gasse, . 2003

机译：生物分子序列分析的生物学发现。案例研究：用于染色质组织的蛋白质和复合物的翻译后修饰
5. Regulation of gypsy chromatin insulator activity and nuclear organization. [D] . Capelson, Maya. 2006

机译：调节吉普赛染色质绝缘子的活性和核组织。
6. Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila. [O] . D A Gdula, T I Gerasimova, V G Corces 1996

机译：果蝇吉普赛染色质绝缘子的遗传和分子分析。
7. Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila. [O] . Gdula, D A, Gerasimova, T I, Corces, V G 1996

机译：果蝇吉普赛染色质绝缘子的遗传和分子分析。

Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila

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