Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

L. A. MacMillan-Crow; John P. Crow; Jeffrey D. Kerby

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Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

机译：锰超氧化物歧化酶的硝化和失活在人肾脏同种异体移植慢性排斥反应中的作用

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Inflammatory processes in chronic rejection remain a serious clinical problem in organ transplantation. Activated cellular infiltrate produces high levels of both superoxide and nitric oxide. These reactive oxygen species interact to form peroxynitrite, a potent oxidant that can modify proteins to form 3-nitrotyrosine. We identified en- hanced immunostaining for nitrotyrosine localized to tubular epithelium of chronically rejected human renal allografts.

机译：慢性排斥反应中的炎症过程仍然是器官移植中的严重临床问题。活化的细胞浸润物产生高水平的超氧化物和一氧化氮。这些活性氧相互作用形成过氧亚硝酸盐，这是一种强氧化剂，可以修饰蛋白质以形成3-硝基酪氨酸。我们鉴定了增强的免疫染色，用于硝基酪氨酸定位于慢性排斥的人类肾脏同种异体移植肾小管上皮细胞。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11853-11858|共6页
作者
L. A. MacMillan-Crow; John P. Crow; Jeffrey D. Kerby;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration [J] . Moreno D.M., Martí M.A., De Biase P.M., Archives of Biochemistry and Biophysics . 2011,第2期

机译：探索酪氨酸34硝化介导的人类锰超氧化物歧化酶失活的分子基础
2. Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury. [J] . Bayir H, Kagan VE, Clark RS, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2007,第1期

机译：实验性和人脑损伤后，神经元NOS介导的硝化作用和大脑中锰超氧化物歧化酶的失活。
3. Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation. [J] . Quint P, Reutzel R, Mikulski R, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2006,第3期

机译：硝化的人类锰超氧化物歧化酶的晶体结构：失活的机制。
4. A novel form of Manganese Superoxide Dismutase: its Role as anti-Cancer, anti- Necrotic and Tumor Marker for Imaging Analysis [C] . Pica A., Di Santi A., Basile F., Proceedings of the world medical conference . 2010

机译：一种新型的锰超氧化物歧化酶：其作为影像分析中的抗癌，抗坏死和肿瘤标记物
5. Kinetic and structural effects of interfacial interruption and protein nitration in human manganese superoxide dismutase. [D] . Quint, Patrick. 2006

机译：人类锰超氧化物歧化酶中界面中断和蛋白质硝化的动力学和结构效应。
6. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. [O] . L A MacMillan-Crow, J P Crow, J D Kerby, 1996

机译：锰超氧化物歧化酶的硝化和失活在人肾同种异体移植的慢性排斥中。
7. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. [O] . MacMillan-Crow, L A, Crow, J P, Kerby, J D, 1996

机译：锰超氧化物歧化酶的硝化和失活在人肾同种异体移植的慢性排斥中。

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

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