Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

Anne G. Ostermeyer; Erik Runko; Blonka Winkfield

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Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

机译：神经母细胞瘤中被细胞质隔离的野生型p53蛋白通过C末端肽重新定位到细胞核

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Cytoplasmic sequestration of wild-type p53 protein occurs in a subset of primary human tumors including breast cancer, colon cancer, and neuroblastoma (NB). The sequestered p53 localizes to punctate cytoplasmic structures that represent large protein aggregates. One functional con- sequence of this blocked nuclear access is impairment of the p53-mediated G1 checkpoint after DNA damage. Here we show that cytoplasmic p53 from NB cells is incompetent for specific DNA binding, probably due to its sequestration.

机译：野生型p53蛋白的细胞质隔离发生在包括乳腺癌，结肠癌和神经母细胞瘤（NB）在内的原发性人类肿瘤的子集中。螯合的p53定位于代表大蛋白聚集体的点状细胞质结构。这种被阻止的核通路的功能性后果是DNA损伤后p53介导的G1检查点的损伤。在这里，我们显示来自NB细胞的胞质p53不适合特定的DNA结合，可能是由于其螯合。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15190-15194|共5页
作者
Anne G. Ostermeyer; Erik Runko; Blonka Winkfield;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. [J] . Moll UM, LaQuaglia M, Benard J, Proceedings of the National Academy of Sciences of the United States of America . 1995,第10期

机译：野生型p53蛋白在未分化的神经母细胞瘤中进行细胞质隔离，但在分化的肿瘤中不进行。
2. Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. [J] . Becker K, Marchenko ND, Maurice M, Cell death and differentiation . 2007,第7期

机译：野生型p53的泛素化作用促进了神经母细胞瘤的胞质隔离。
3. Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53 [J] . Markowitz J, Rustandi RR, Varney KM, Biochemistry . 2005,第19期

机译：S100B野生型和EF手段突变体在存在和不存在P53衍生的肽的存在和不存在肽中的钙结合特性
4. Detection of serum anti-p53 antibodies in cancer that uses recombined wild-type p53 protein and phage displayed peptide [C] . The 5th International Conference on Computer Sciences and Convergence Information Technology . 2010

机译：使用重组的野生型p53蛋白和噬菌体展示肽检测癌症中的血清抗p53抗体
5. Characterization of the A. thaliana cytoplasmic tRNA export protein (CTEXP) and investigation of retrograde tRNA movement to the nucleus in plant cells. [D] . Johnstone, Aaron. 2010

机译：拟南芥胞质tRNA输出蛋白（CTEXP）的特征以及逆转录tRNA向植物细胞内核运动的研究。
6. Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide [O] . Anne G. Ostermeyer, Erik Runko, Blonka Winkfield, 1996

机译：细胞质隔离的野生型p53蛋白神经母细胞瘤通过C末端肽重定位到核
7. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. [O] . Moll, U M, LaQuaglia, M, Bénard, J, 1995

机译：野生型p53蛋白在未分化的神经母细胞瘤中进行细胞质隔离，但在分化的肿瘤中不进行。

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

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