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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.
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Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

机译：鲨鱼，一种Src同源性2，锚蛋白重复序列​​，酪氨酸激酶在外胚层上皮的顶表面表达。

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摘要

Tyrosine kinases, ankyrin repeats, and Src homology 2 domains play central roles in developmental processes. The cloning of a cDNA for Shark, a single protein that possesses all three domains, is described. During Drosophila embryogenesis, Shark is expressed exclusively by ectodermally derived epithelia and is localized preferentially to the apical surface of these cells. This apical localization persists, even as tissues undergo complex invaginations, moving from the external surface of embryos to form internal structures, but expression is lost when cells lose their polarity. This pattern closely mimics the expression of Crumbs, a protein necessary for proper organization of ectodermal epithelia. Shark's structure and localization pattern suggest that it functions in a signaling pathway for epithelial cell polarity, possibly transducing the Crumbs signal.
机译：酪氨酸激酶，锚蛋白重复序列​​和Src同源性2结构域在发育过程中起着核心作用。描述了鲨鱼的cDNA的克隆，鲨鱼是具有所有三个结构域的单个蛋白质。果蝇胚胎发生过程中，鲨鱼只由外胚层衍生的上皮细胞表达，并优先定位于这些细胞的顶表面。即使组织经历复杂的侵袭，这种顶端的定位仍然存在，从胚胎的外表面移动到内部结构，但是当细胞失去极性时表达就会丢失。这种模式紧密模拟了Crumbs的表达，Crumbs是外胚层上皮的正确组织所必需的蛋白质。鲨鱼的结构和定位模式表明，它在上皮细胞极性的信号传导途径中起作用，可能是转导了Crumps信号。

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