INTERACTIONS OF A REL PROTEIN WITH ITS INHIBITOR

Lehming N.; Brickman JM.; Ptashne M.; Mcguire S.

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INTERACTIONS OF A REL PROTEIN WITH ITS INHIBITOR

机译：REL蛋白与其抑制剂的相互作用

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Cactus, a Drosophila homologue of I kappa B, binds to and inhibits Dorsal, a homologue of the p50 and p65 components of NF-kappa B. We describe experiments in yeast with various Dorsal and Cactus derivatives showing that Cactus blocks the DNA binding and nuclear localization functions of Dorsal. In contrast, Dorsal's transcriptional activating region is functional in the Dorsal-Cactus complex. We identify two Dorsal mutants, Dorsal C233R and Dorsal S234P, that escape Cactus inhibition in vivo, and we show that these mutants fail to interact with Cactus in vitro. From this and data of others, we identify the likely surface of Dorsal that binds Cactus. We also describe a modified PCR mutagenesis procedure, easier to use than conventional methods, that produces a library of high complexity. [References: 25]

机译：仙人掌是果蝇B的果蝇同源物，它结合并抑制NF-κB的p50和p65组分的同源物Dorsal。我们描述了在酵母中进行的各种Dorsal和Cactus衍生物的实验，显示仙人掌阻止了DNA的结合和核背侧定位功能。相反，背侧的转录激活区在背侧仙人掌复合物中起作用。我们确定了两个背对背突变体，背对背C233R和背对S234P，逃避了体内的仙人掌抑制作用，并且我们表明这些突变体无法与仙人掌在体外相互作用。根据这些数据和其他数据，我们确定了与仙人掌结合的背侧表面。我们还描述了一种经过修饰的PCR诱变程序，它比传统方法更易于使用，可产生高度复杂的库。 [参考：25]

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第22期|p. 10242-10246|共5页
作者
Lehming N.; Brickman JM.; Ptashne M.; Mcguire S.;
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作者单位

HARVARD UNIV DEPT MOLEC & CELLULAR BIOL 7 DIVIN AVE CAMBRIDGE MA 02138 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Ankyrin repeats; Protein-protein interaction; Rel domain; Nf-kappa-b; Nuclear-localization; Drosophila embryo; Saccharomyces-cerevisiae; Dorsoventral pattern; Mammalian-cells; Dna-binding; Gene; Yeast; Expression;

机译：锚蛋白重复;蛋白-蛋白质相互作用;Rel结构域;Nf-kappa-b;核定位;果蝇胚胎;酿酒酵母;腹腔模式;哺乳动物细胞;Dna结合;基因;酵母;表达;

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专利

1. Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo. [J] . D W White, G A Pitoc, T D Gilmore Molecular and Cellular Biology . 1996,第3期

机译：v-Rel癌蛋白与NF-kappaB和IkappaB蛋白的相互作用：转化缺陷型v-Rel突变体和NF-2的异二聚体在体外和体内均具有功能。
2. Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. [J] . X Xu, C Prorock, H Ishikawa, Molecular and Cellular Biology . 1993,第11期

机译：v-Rel和c-Rel癌蛋白与TATA结合蛋白的功能相互作用以及与转录因子IIB的关联。
3. Glucosamine inhibits lipopolysaccharide-stimulated inducible nitric oxide synthase induction by inhibiting expression of NF-kappaB/Rel proteins at the mRNA and protein levels [J] . Hwang S.-Y., Hwang J.-S., Kim S.-Y., Nitric oxide: Biology and chemistry . 2013,第Null期

机译：葡萄糖胺通过在mRNA和蛋白水平上抑制NF-κB/ Rel蛋白的表达来抑制脂多糖刺激的一氧化氮合酶的诱导
4. Development of Peptide Inhibitors Disrupting PCSK9-LDLR Protein-Protein Interactions [C] . Kevin Ly, Anna Kwiatkowska, Sophie Routhier American Peptide Symposium . 2013

机译：肽抑制剂的研制破坏PCSK9-LDLR蛋白质 - 蛋白质相互作用
5. Toward Better Development of Protein-Protein Interaction Inhibitors: Applications to the beta-Catenin/T-Cell Factor Protein-Protein Interaction [D] . Catrow, Jonathan Leon. 2017

机译：寻求更好的蛋白质-蛋白质相互作用抑制剂的开发：在β-Catenin/ T细胞因子蛋白质-蛋白质相互作用中的应用
6. Interactions of a Rel protein with its inhibitor. [O] . N Lehming, S McGuire, J M Brickman, 1995

机译：Rel蛋白与其抑制剂的相互作用。
7. Interactions of a Rel protein with its inhibitor. [O] . Lehming, N, McGuire, S, Brickman, J M, 1995

机译：Rel蛋白与其抑制剂的相互作用。

INTERACTIONS OF A REL PROTEIN WITH ITS INHIBITOR

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