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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >PASSIVE IMMUNOTHERAPY FOR RETROVIRAL DISEASE - INFLUENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX TYPE AND T-CELL RESPONSIVENESS
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PASSIVE IMMUNOTHERAPY FOR RETROVIRAL DISEASE - INFLUENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX TYPE AND T-CELL RESPONSIVENESS

机译：被动免疫疗法治疗肠道疾病-主要组织相容性复合体类型和T细胞反应性的影响

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Administration of virus-specific antibodies is known to be an effective early treatment for some viral infections. Such immunotherapy probably acts by antibody-mediated neutralization of viral infectivity and is often thought to function independently of T-cell-mediated immune responses. In the present experiments, we studied passive antibody therapy using Friend murine leukemia virus complex as a model for an immunosuppressive retroviral disease in adult mice. The results showed that antibody therapy could induce recovery from a well-established retroviral infection. However, the success of therapy was dependent on the presence of both CD4(+) and CD8(+) T lymphocytes. Thus, cell-mediated responses were required for recovery from infection even in the presence of therapeutic levels of antibody. The major histocompatibility type of the mice was also an important factor determining the relative success of antibody therapy in this system, but it was less critical for low-dose than for high-dose infections. Our results imply that limited T-cell responsiveness as dictated by major histocompatibility genes and/or stage of disease may have contributed to previous immunotherapy failures in AIDS patients. Possible strategies to improve the efficacy of future therapies are discussed. [References: 65]
机译：已知给予病毒特异性抗体是对某些病毒感染的有效早期治疗。这种免疫疗法可能通过抗体介导的病毒感染性中和起作用，并且通常被认为独立于T细胞介导的免疫反应而起作用。在本实验中，我们研究了使用Friend鼠白血病病毒复合物作为成年小鼠免疫抑制逆转录病毒疾病模型的被动抗体疗法。结果表明，抗体疗法可诱导从公认的逆转录病毒感染中恢复。但是，治疗的成功取决于CD4（+）和CD8（+）T淋巴细胞的存在。因此，即使在治疗水平的抗体存在下，也需要细胞介导的反应才能从感染中恢复。小鼠的主要组织相容性类型也是决定该系统中抗体治疗相对成功的重要因素，但对于低剂量感染而言，它的重要性不如对高剂量感染而言。我们的结果表明，主要组织相容性基因和/或疾病阶段所决定的有限的T细胞反应性可能已导致艾滋病患者先前的免疫治疗失败。讨论了提高未来治疗效果的可能策略。 [参考：65]

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