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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >EMERGENCE OF THE ZNF91 KRUPPEL-ASSOCIATED HOX-CONTAINING ZINC FINGER GENE FAMILY IN THE LAST COMMON ANCESTOR OF ANTHROPOIDEA
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EMERGENCE OF THE ZNF91 KRUPPEL-ASSOCIATED HOX-CONTAINING ZINC FINGER GENE FAMILY IN THE LAST COMMON ANCESTOR OF ANTHROPOIDEA

机译：ZNF91的KRUPPEL关联的含HOX的锌指基因家族在人类最后一个共同祖先中的出现

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摘要

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the emergence and evolutionary conservation of the ZNF91 family, ZNF91 family members were detected in all species of great apes, gibbons, Old World monkeys, and New World monkeys examined but were not found in prosimians or rodents, In each species containing the ZNF91 family, the genes were clustered at one major site, on the chromosome(s) syntenic to human chromosome 19, To identify a putative ''founder'' gene, >20 murine KRAB-containing zinc finger protein (ZFP) cDNAs were randomly cloned, but none showed sequence similarity to the ZNF91 genes. These observations suggest that the ZNF91 gene cluster is a derived character specific to Anthropoidea, resulting from a duplication and amplification event some 55 million years ago in the common ancestor of simians. Although the ZNF91 gene cluster is present in all simian species, the sequences of the human ZNF91 gene that confer DNA-binding specificity were conserved only in great apes, suggesting that there is not a high selective pressure to maintain the DNA targets of these proteins during evolution. [References: 41]
机译：ZNF91基因家族是包含Kruppel关联盒（KRAB）的锌指基因组的子集，包含40个以上的基因座。大多数驻留在人类19p12-p13.1染色体上。我们已经检查了ZNF91家族的出现和进化保守性，在所研究的所有大猿，长臂猿，旧世界猴和新世界猴物种中均检测到ZNF91家族成员，但在prosimians或啮齿动物中均未发现ZNF91家族成员。 ZNF91家族，这些基因聚集在一个与人类19号染色体同系的染色体上的一个主要位点上，为鉴定推定的“奠基人”基因，随机抽取了20个以上含鼠KRAB的锌指蛋白（ZFP）cDNA克隆，但没有显示出与ZNF91基因的序列相似性。这些观察结果表明，ZNF91基因簇是拟南芥特有的衍生特征，这是由于大约5500万年前在猿猴的祖先中发生的复制和扩增事件所致。尽管ZNF91基因簇存在于所有猿猴物种中，但赋予DNA结合特异性的人ZNF91基因的序列仅在大猿猴中保守，这表明在维持这些蛋白的DNA靶标方面没有很高的选择压力。演化。 [参考：41]

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