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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A distinct lineage of influenza A virus from bats
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A distinct lineage of influenza A virus from bats

机译：来自蝙蝠的独特的甲型流感病毒谱系

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摘要

Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses circulate in waterfowl, but those that infect mammalian hosts are thought to pose the greatest risk for zoonotic spread to humans and the generation of pandemic or panzootic viruses. We have identified an influenza A virus from little yellow-shouldered bats captured at two locations in Guatemala. It is significantly divergent from known influenza A viruses. The HA of the bat virus was estimated to have diverged at roughly the same time as the known subtypes of HA and was designated as H17. The neuraminidase (NA) gene is highly divergent from all known influenza NAs, and the internal genes from the bat virus diverged from those of known influenza A viruses before the estimated divergence of the known influenza A internal gene lineages. Attempts to propagate this virus in cell cultures and chicken embryos were unsuccessful, suggesting dis tinct requirements compared with known influenza viruses. Despite its divergence from known influenza A viruses, the bat virus is compatible for genetic exchange with human influenza viruses in human cells, suggesting the potential capability for reas sortment and contributions to new pandemic or panzootic influ enza A viruses.
机译：动物中的甲型流感病毒库提供了新颖的遗传因素，导致人类大流行性大流行的出现。大多数甲型流感病毒在水禽中传播，但那些感染哺乳动物宿主的病毒被认为对人畜共患病的传播以及大流行或大流行病毒的产生具有最大的风险。我们已经从在危地马拉两个地点捕获的黄色带肩蝙蝠中识别出甲型流感病毒。它与已知的甲型流感病毒明显不同。估计蝙蝠病毒的HA与已知的HA亚型大致在同一时间发散，并命名为H17。神经氨酸酶（NA）基因与所有已知的流感NA高度不同，并且蝙蝠病毒的内部基因在与已知的A型流感内部基因谱系发生差异之前就与已知的A型流感病毒不同。尝试在细胞培养物和鸡胚中繁殖这种病毒没有成功，这表明与已知的流感病毒相比有不同的要求。尽管蝙蝠病毒与已知的A型流感病毒有所不同，但它仍可与人类流感病毒在人类细胞中进行基因交换，这表明它具有重新分类的潜力以及对新的大流行性或大流行性A型流感病毒的贡献。

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  • 作者

    Suxiang Tong; Yan Li; Pierre Rivailler; Christina Conrardy; Danilo A. Alvarez Castillo; Li-Mei Chen; Sergio Recuenco; James A. Ellison; Charles T. Davis; Ian A. York; Amy S. Turmelle; David Moran; Shannon Rogers; Mang Shi; Ying Tao; Michael R. Weil; Kevin Tang; Lori A. Rowe; Scott Sammons; Xiyan Xu; Michael Frace; Kim A. Lindblade; Nancy J. Cox; Larry J. Anderson; Charles E. Rupprecht; Ruben O. Donis;

  • 作者单位

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Center for Health Studies, Universidad del Valle de Guatemala,01015, Guatemala City, Guatemala;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    Division of High Consequence Pathogens and Pathology Disease Control and Prevention, Atlanta, GA 30333;

    Division of High Consequence Pathogens and Pathology Disease Control and Prevention, Atlanta, GA 30333;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    Division of High Consequence Pathogens and Pathology Disease Control and Prevention, Atlanta, GA 30333;

    Center for Health Studies, Universidad del Valle de Guatemala,01015, Guatemala City, Guatemala;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Emory University, Atlanta, GA 30322;

    Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA 30333;

    Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA 30333;

    Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA 30333;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA 30333;

    International Emerging Infections Program, Centers for Disease Control and Prevention Regional Office for Central America and Panama, 01015, Guatemala City, Guatemala;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

    Division of Viral Diseases Disease Control and Prevention, Atlanta, GA 30333;

    Division of High Consequence Pathogens and Pathology Disease Control and Prevention, Atlanta, GA 30333;

    lnfluenza Division Disease Control and Prevention, Atlanta, GA 30333;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    evolution; host range; orthomyxoviridae; chiroptera; central america;

    机译：演化;主机范围;正粘病毒科;翼手目中美洲;

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